Frailty Among Renal Transplant Recipients and Relation to Chronic Allograft Dysfunction

Study of Frailty Among Renal Transplant Recipients, Its Relation to Chronic Renal Allograft Dysfunction

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07181096

Enrollment

Registered

2025-09-18

Start date

2025-07-15

Completion date

2026-01-15

Last updated

2025-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Frailty, Renal Transplant

Keywords

Frailty, renal transplant recipient, chronic allograft dysfunction

Brief summary

The aim of the study is to assess prevalence of frailty among renal transplant recipients in Alexandria University Hospitals and to study the relation between frailty and chronic allograft dysfunction.

Detailed description

With respect to correlates of frailty, although higher comorbidity burden is also a risk factor for frailty among KT candidates, frailty can also occur in the setting of lower comorbidity burdens. Diabetes and serum albumin concentration are also associated with frailty among prevalent dialysis patients. In addition, individuals with CKD and ESKD who are frail are also more likely to have cognitive impairment and sarcopenia, or low muscle mass, than their non-frail counterparts

Interventions

DIAGNOSTIC_TESTassessment of frailty

This study is a prospective cross-sectional study to assess the prevalence of frailty among 80 cases of renal transplanted patients. Specific tests will include: 1. Assessment of frailty by Clinical Frailty Scale. 2. Assessment of nutritional status using Patient Generated Subjective Global Assessment (PG-SGA). 3. Comorbidity assessment using Charlson comorbidity score. 4. Six minutes walk test. 5. Muscle strength assessment using hand grip strength (HGS) dynamometer.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Renal transplanted patients with GFR more than 30

Exclusion criteria

* Mentally or physically unfit patients. * Amputation of lower limb. * Active neoplasia, chronic liver disease, previous immunological disease. * Psychiatric disorders. * Pregnancy.

Design outcomes

Primary

Measure	Time frame	Description
Assessment of frailty	30 days	by Clinical Frailty Scale.

Secondary

Measure	Time frame	Description
Assessment of nutritional status	30 days	using Patient Generated Subjective Global Assessment (PG-SGA)
Comorbidity assessment	30 days	using Charlson comorbidity score
Muscle strength assessment	30 days	using hand grip strength (HGS) dynamometer.

Countries

Egypt

Contacts

Primary ContactMohamed mamdouh Elsayed, MD

dr_mohamedmamdouh87@yahoo.com00201068055103

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026