CART Cells, Monocytes, Multiple Myeloma
Conditions
Keywords
Multiple myeloma, Monocytes, CART cells, Microenvironment
Brief summary
Tumoral micro-environment in malignant haematological diseases, notably in multiple myeloma, is active on plasma cells survival and proliferation. Monocytosis and monocytes typing are described in multiple myeloma response as factors on proliferation and cell death evasion. CART cells have improved multiple myeloma care in last 5 years, nethertheless, early relapse occur and we must identify predictor factors of better response. The aim of this study is to analyze basic level and phenotyping of monocytes before and after CART cells infusion and study their impact on multiple myeloma response
Interventions
None listed
Sponsors
Centre Hospitalier Universitaire, Amiens
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients over 18 years old * Treated for a multiple myeloma * CART cells treatment proposed * Affiliated to social security system * Agreed to participate to the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall response rate | day 1 |
Secondary
| Measure | Time frame |
|---|---|
| Progression free survival | 3 years |
| Overall survival | 3 years |
| time to next treatment | 3 years |
Countries
France
Contacts
Primary ContactLydia Montes, MD
Outcome results
None listed