Comparing the Antiplaque Effects of Novel Titania Nanoparticle Infused Fluoride Varnish vs Conventional Fluoride Varnish in Fixed Orthodontic Patients.

Comparing the Antiplaque Efficacy of Titania Nanoparticle Infused Fluoride Varnish vs Conventional Fluoride Varnish in Fixed Orthodontic Patients-A Triple Blind Randomised Controlled Trial.

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07180849

Enrollment

Registered

2025-09-18

Start date

2025-11-30

Completion date

2027-12-31

Last updated

2025-09-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Plaque Accumulation, Fluoride Varnishes, Nanoparticles

Brief summary

In this study the investigators aimed to explore the antibiofilm effect of fluoride varnish loaded with titania nanoparticles synthesized from moringa oleifera leaves extract vs conventional fluoride varnish in multibracket fixed orthodontic patients.

Interventions

PROCEDUREFluoride varnish

Group A will receive conventional fluoride varnish for antiplaque effects.Plaque will be assessed quantitatively by modified plaque index.

PROCEDURENovel titania nanoparticle infused fluoride varnish

Group B will receive topical application of titania nanoparticle infused fluoride varnish for antiplaque effects.Plaque will be assessed quantitatively by modified plaque index.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

16 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients planned for fixed orthodontic treatment. * Patients within age group 16-30 years. * Patient with no history of previous orthodontic treatment. * Patients with no active periodontal diseases.

Exclusion criteria

* Patient undergoing any antibiotic therapy. * Patients with any craniofacial abnormality. * Patient with mixed dentition

Design outcomes

Primary

Measure	Time frame	Description
To compare the plaque inhibitory effect of titania nanoparticle infused fluoride varnish and conventional fluoride varnish in fixed orthodontic patients.	6 months	Plaque will be assessed quantitatively by modified plaque index.

Secondary

Measure	Time frame	Description
To measure plaque bacterial load and pH following application of titania nanoparticle infused and conventional fluoride varnish in fixed orthodontic patients.	6 months	Bacterial colonies will be morphologically identified and counted as Colony Forming Units (CFU) using a colony counting grid.

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026