Stutter, Stuttering, Stuttering, Adult, Stuttering, Developmental
Conditions
Keywords
Magnetic Resonance Imaging (MRI) scans, Behavioral assessments
Brief summary
The overall objective of this study is to examine inter effector areas (IEAs) activity and functional connectivity during continuous speech production in stuttering adults.
Interventions
BEHAVIORALSpeech Production During functional magnetic resonance imaging (MRI)
Participants will complete a speech production task with 2 conditions (stuttered, non-stuttered) while undergoing functional MRI to assess brain activity. Brain activity will be compared within subjects for the 2 conditions. The intervention is the combination of tasks delivered to all participants. The speaking task is the intervention (modifying agent) and the MRI is a measurement tool, not a therapeutic or modifying agent.
Sponsors
University of Michigan
National Institute on Deafness and Other Communication Disorders (NIDCD)
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
There will be 50 adults that stutter that participate in this study with a goal of 33 evaluable.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Are between the ages of 18-65 years * Have otherwise normal speech, language, hearing and cognition * Speak English as their primary language * Currently stutter
Exclusion criteria
* Have serious medical or neurological conditions (e.g., stroke, traumatic brain injury, Parkinson's disease, etc.) * Have had a closed head injury (e.g., concussion) * Have a reading disorder (e.g., dyslexia) * Have hearing loss * Have metal or electronic implants (e.g., cochlear implants, pacemakers, etc.) * Are currently pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood-Oxygen-Level-Dependent (BOLD) signal change during speaking | During the speech task (5 runs, 8 minutes each) distributed across MRI Visits 1-6, up to 12 months from enrollment. | The Blood-oxygen-level-dependent (BOLD) signal reflects changes in blood oxygenation levels that are associated with neural activity. It is measured using functional magnetic resonance imaging (fMRI) and reported in arbitrary units (a.u.). The BOLD response provides an indirect index of localized brain activity during task performance, with increased signal indicating greater activation in a given brain region relative to baseline or a comparison condition. In this study, BOLD signal differences will be compared within participants across two speech production tasks: (1) stuttered speech and (2) non-stuttered speech. Each participant will complete the speech task on several of the MRI visits, which varies per participant (total amount of time spent will be the same across participants). |
Countries
United States
Contacts
CONTACTEmily Garnett, PhD
PRINCIPAL_INVESTIGATORSoo-Eun Shang, PhD
University of Michigan
Outcome results
None listed