Aortic Valve Stenosis
Conditions
Brief summary
The aim of this study is to evaluate the combined utility of the left atrial coupling index (LACI) and left ventricular speckle tracking echocardiography (LVSTE) in improving risk stratification and outcome prediction for patients undergoing Transcatheter Aortic Valve Implantation (TAVI). This study seeks to identify novel prognostic markers that enhance the prediction of mortality, heart failure, and functional recovery, ultimately enabling more personalized clinical decision-making and optimized patient outcomes by integrating the advanced echocardiographic parameters into pre-procedural assessments,.
Detailed description
Transcatheter Aortic Valve Implantation (TAVI) has emerged as a transformative procedure for patients with severe aortic stenosis, particularly those at high surgical risk. However, accurately predicting patient outcomes remains a significant challenge, necessitating improved risk stratification tools. This study aims to evaluate the role of the left atrial coupling index (LACI) and left ventricular speckle tracking echocardiography (LVSTE) in enhancing outcome prediction in patients undergoing TAVI. By integrating advanced echocardiographic parameters, such as LACI, which reflects left atrial function and ventricular-atrial interaction, and LVSTE, a sensitive measure of myocardial deformation, this research seeks to uncover novel prognostic markers. A prospective cohort of TAVI patients will be studied to assess the association between these indices and post-procedural outcomes, including Repeated hospitalization, heart failure, stroke and myocardial infarction.
Interventions
evaluate the role of the left atrial coupling index (LACI) and left ventricular speckle tracking echocardiography (LVSTE) in enhancing outcome prediction in patients undergoing TAVI.
Sponsors
medina medical center
Tanta University
Damanhour University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to 102 Years
Inclusion criteria
* Patients diagnosed with severe aortic stenosis and scheduled for TAVI.
Exclusion criteria
* Patients with significant mitral or tricuspid valve disease requiring intervention. * History of atrial fibrillation or other arrhythmias that preclude accurate LACI measurement. * Poor echocardiographic window preventing reliable imaging.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Need for permanent pacemaker | 6 months | number of patients need for permanent pacemaker |
| Repeated hospitalization in one year | one year | number of patients need rehospitalization |
| Myocardial infarction within one year | one year | incidence of MI in patients |
| Stroke in one year | one year | incidence of stroke in patients |
Countries
Egypt, Saudi Arabia
Outcome results
None listed