Perioperative Myocardial Injury
Conditions
Keywords
troponin, Perioperative myocardial injury
Brief summary
Myocardial injury during non-cardiac surgery (PMI) affects up to 16% of high-risk patients and represents a significant burden on healthcare systems. An acute myocardial infarction is defined by a dynamic increase in cardiac troponin (cTn) above the 99th percentile and is accompanied by clinical signs of myocardial ischemia. Myocardial injury, on the other hand, is characterized by an increase in cardiac troponin, but without meeting the diagnostic criteria for myocardial infarction. In the perioperative interval, however, it is irrelevant whether a myocardial infarction according to the universal definition or merely an increase in troponin is present, as there is no difference in mortality between the two patient groups. The comprehensive study by Botto et al. provides valuable insights into the severity of MINS and found that 8.0% of patients met the diagnostic criteria. An important finding of this study is that the majority of MINS cases (87.1%) occurred within the first two days after surgery, highlighting the immediate risk of the condition (Botto et al., 2014). We would like to emphasize the necessity of our prospective, multicenter observational study by highlighting anesthesia-dependent variables such as hemodynamics, type of medication, their potential role, and surgical aspects such as duration of surgery, which represent risk factors for MINS. Identifying and understanding modifiable and non-modifiable risk factors is essential for targeted preoperative intervention. Understanding these factors is crucial for subsequent interventional studies and can also provide criteria for increased monitoring of high-risk patients, as suggested in the current guidelines.
Interventions
None listed
Sponsors
University Hospital Tuebingen
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Elective or emergency non-cardiac surgery * Cardiovascular risk: At least two of the following: Age \>60 years, hypertension, diabetes mellitus, coronary heart disease, peripheral arterial occlusive disease, cerebrovascular disease, chronic renal insufficiency, chronic heart failure, chronic obstructive pulmonary disease, active smoking * Age criteria: Adults aged 40-80 years. * ASA status: ASA classification II-IV. * Written consent after prior explanation
Exclusion criteria
* o Patients unable to give consent: intubated and sedated patients * Types of surgery: cardiac surgery, including coronary artery bypass grafting, heart valve repair or replacement, and heart transplantation; obstetric procedures, including cesarean section; minor surgical procedures that do not require general or regional anesthesia (e.g., minor dermatological or ophthalmological procedures) * Cardiovascular risk: patients without at least two of the following risk factors: age \<40 or \>80, no history of hypertension, diabetes, coronary artery disease, peripheral arterial disease, cerebrovascular disease, chronic renal failure, chronic heart failure, chronic obstructive pulmonary disease, and non-smoker status * Age criteria: Patients under 40 or over 80 years of age * ASA status: ASA classification of I.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Troponin | 1-5 days | Development of Troponin after non-cardiac surgery |
| incidence of PMI | 1-5 days | incidence of PMI after non-cardiac surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mortality | 1-30 days | Mortality after non-cardiac surgery |
Countries
Germany
Contacts
Primary ContactMichael Koeppen, MD
Backup ContactSibel Sari-Yavuz, MD
Outcome results
None listed