A Study of SCAD Using Stress Contrast Echocardiography

Myocardial Perfusion in Spontaneous Coronary Artery Dissection Using Stress Contrast Echocardiography

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07178509

Enrollment

Registered

2025-09-17

Start date

2025-11-25

Completion date

2027-09-30

Last updated

2026-01-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spontaneous Coronary Artery Dissection

Brief summary

This study aims to fill knowledge gaps regarding microvascular perfusion and pressor response to stress among patients with history of spontaneous coronary artery dissection (SCAD) using stress contrast echocardiography.

Interventions

PROCEDUREStress Echocardiography with Contrast

Stress Echocardiography with Contrast will be used to assess heart function and blood flow response to stressors.

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Adult \>18 years old * Patient has a history of spontaneous coronary artery dissection (SCAD) OR patient is healthy with no significant medical history

Exclusion criteria

* Unable to give consent * Allergic or have a history of adverse reaction to dobutamine, the Definity® ultrasound enhancing agent, or atropine. * Has a known or suspected hypersensitivity to perflutren and therefore cannot be given Definity®. * Pregnant. * Unable to interrupt breastfeeding. * Within 3 months of a heart attack. * Severe aortic stenosis. * Severe, uncontrolled hypertension (\>200/110 mmHg at baseline).

Design outcomes

Primary

Measure	Time frame	Description
Change in Microvascular Function	Baseline, immediately after the Stress Echocardiography	Microvascular Function will be determined by Microvascular Blood Flow (Liters/Minute). Microvascular Blood Flow will be measured by a stress echocardiogram with contrast. A higher Microvascular Blood Flow indicated better blood flow circulation.
Change in Blood Pressure	Baseline, immediately after the Stress Echocardiography	Change is blood pressure will be measured by a stress echocardiogram with contrast (mmHg).
Change in Heart Rate	Baseline, immediately after the Stress Echocardiography	Change in heart rate will be measured by a stress echocardiogram with contrast (beats per minute).

Countries

United States

Contacts

Primary ContactPamela Engrav

engrav.pamela@mayo.edu507-255-6938

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026