Idiopathic Pulmonary Fibrosis (IPF), Sarcopenia
Conditions
Keywords
idiopathic pulmonary fibrosis, sarcopenia, skeletal muscle mass index, bioelectrical impedance analysis
Brief summary
Sarcopenia negatively affects the prognosis of chronic diseases. However, the importance of sarcopenia in patients with idiopathic pulmonary fibrosis (IPF) has been less emphasized. The aim of the study is to determine the prevalence of sarcopenia in patients with IPF and to evaluate the impact of sarcopenia on quality of life and disease progression. This study was designed as a descriptive cross-sectional. The study included patients diagnosed with IPF. Hand dynamometry and bioelectrical impedance analysis (BIA) were used to for diagnose of sarcopenia. Pulmonary function tests, maximal inspiratory pressure (MIP), and maximal expiratory pressure (MEP) measurements were examined. The 6-minute walk distance (6MWD) and 4-meter walking speed were recorded. The St. George Respiratory Questionnaire (SGRQ) was used to assess quality of life. All patients were evaluated for progressive disease.
Detailed description
The study was designed as a cross-sectional study.
Interventions
None listed
Sponsors
Mersin University
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Being over 18 years of age * Signing the informed consent form * Having a diagnosis of IPF for at least one month
Exclusion criteria
* Pregnancy * History of cancer within the last 5 years * History of lung surgery * History of neuromuscular disease * Active pulmonary tuberculosis * Active respiratory tract infection * Inability to perform pulmonary function tests * Presence of a pacemaker * History of systemic steroid use within the past 3 months * Inability to use a hand dynamometer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Progressive Disease | through study completion, an average of 1 year | Examination of all participants from clinical, physiological, and radiological perspectives |
| Hand Grip Strength | through study completion, an average of 1 year | Hand Grip Strength (kg)- Grip strength measurement using a hand dynamometer |
| SMI (skeletal muscle mass index) | through study completion, an average of 1 year | SMI (skeletal muscle mass index) (kg/m2) - SMI measurement using the Bioelectrical Impedance Analysis (BIA) device |
| Forced Expiratory Volume in 1 second (FEV1) | through study completion, an average of 1 year | Measurement of FEV1 for the assessment of pulmonary function |
| Forced Vital Capacity (FVC) | through study completion, an average of 1 year | Measurement of FVC for the assessment of pulmonary function |
| Diffusing Capacity of The Lungs for Carbon Monoxide (DLCO) | through study completion, an average of 1 year | Measurement of DLCO for the assessment of pulmonary function. |
| Total Lung Capacity (TLC) | through study completion, an average of 1 year | Measurement of TLC for the assessment of pulmonary function. |
| Respiratory Muscle Strength | through study completion, an average of 1 year | Measurement of maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) for assessment of respiratory muscle strength |
| Six Minute Walk Test (6MWT) | through study completion, an average of 1 year | Distance walked in six minutes (m) |
| Gait speed | through study completion, an average of 1 year | 4-meter walking speed (m/s) |
| St. George's Respiratory Questionnaire (SGRQ) | through study completion, an average of 1 year | The questionnaire is designed to measure quality of life. It consists of symptom, activity, impact, and total scores. Each score ranges from 0 to 100. High scores indicate lower quality of life. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Body Mass Index ( BMI) | through study completion, an average of 1 year | kg/m2 |
Countries
Turkey (Türkiye)
Outcome results
None listed