Management of Medication Related Osteonecrosis of the Jaws With Double Periosteal Flap Closure

Management of Medication Related Osteonecrosis of the Jaws Using Piezosurgery With Simultaneous Double Periosteal Flap Closure

Status

Enrolling by invitation

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07177378

Enrollment

Registered

2025-09-17

Start date

2025-01-03

Completion date

2026-12-26

Last updated

2026-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteomyelitis of Jaw

Keywords

medication related osteonecrosis, mandible, piezosurgery

Brief summary

20 patients with MRONJ underwent surgical debridement using piezosurgery then closure using double periosteal flap

Detailed description

20 patients with MRONJ underwent surgical debridement, crestal incision and oblique releasing incision were performed to expose the area of osteomyelitis, then squesterum was removed using piezosurgery. After complete debridement, the periosteal layer was dissected from mucoperiosteal buccal flap and based superiorly, then turn upward to be sutured to the lingual flap followed by suturing of buccal flap to achieve double layers closure

Interventions

DEVICEmanagement of medication related osteonecrosis of the jaw

after buccal flap reflection, the bone osteonecrosis was debrided using piezosurgery. the buccal mucoperiosteal flap was dissected to two layers first, the periosteal layer was based superiorly and the mucosal flap to achieve double layers closure.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Intervention model description

patient with medication related osteonecrosis of the mandible underwent surgical debridement and closure using double periosteal flap

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

• patients with MRONJ

Exclusion criteria

* Patients had a history of radiotherapy * Patients need only conservative treatment

Design outcomes

Primary

Measure	Time frame	Description
evaluation of pain	one month	visual analog scale (VAS), with 0 indicating no pain and 10 indicating the most severe pain.
wound healing	one -3 months	the wound healing index (WHI) which scored soft tissue healing according to the following criteria: score 1 = uneventful healing with no gingival edema, erythema, suppuration, patient discomfort, or flap dehiscence; score 2 = uneventful healing with slight gingival edema, erythema, patient discomfort, or flap dehiscence, but no suppuration; and score 3 = poor wound healing with significant gingival edema, erythema, patient discomfort, flap dehiscence, or any suppuration

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 20, 2026