Evaluation of Skin Stiffness Changes in Wounds Before and After Low-Level Laser Therapy

Evaluation of Skin Stiffness Changes in Wounds Before and After Low-Level Laser Therapy Using 660 nm Laser: A Comparative Analysis With OCT and MyotonPRO

Status

Active, not recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07177274

Enrollment

Registered

2025-09-16

Start date

2024-09-19

Completion date

2025-09-20

Last updated

2025-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Wound - in Medical Care

Keywords

Stiffness, Wound, Skin, Low-Level Laser Therapy

Brief summary

Chronic wounds and impaired healing remain a major clinical challenge, particularly in patients with diabetes, vascular disease, or age-related skin fragility. Low-level laser therapy (LLLT) at 660 nm has been reported to enhance tissue repair, reduce inflammation, and promote angiogenesis. However, the biomechanical properties of wound tissue following LLLT remain poorly understood. Optical Coherence Tomography (OCT) provides a non-invasive, high-resolution method to assess skin microstructure and elasticity, while the MyotonPRO offers quantitative stiffness measurements at the tissue surface. Combining these two complementary modalities may provide a more comprehensive assessment of wound healing progression and treatment response. This study aims to evaluate changes in wound stiffness before and after 660 nm LLLT and to compare them against contralateral normal skin, thereby providing objective insight into the biomechanical efficacy of laser treatment.

Interventions

RADIATIONLow Level Laser Therapy

Collecting wound stiffness data using the OCT-air-jet and Myoton Pro before and after the LLLT treatment using the device's indentation system. Then the intervention is applying LLLT to the wound for 3 min. The LLLT utilized the Red Dot Laser Diode Module Class IIIA.

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* presented chronic and burn wounds lasting more than four weeks. * had partial-thickness burn wounds.

Exclusion criteria

* current smokers. * wounds that were fresh and still bleeding.

Design outcomes

Primary

Measure	Time frame
To evaluate changes in skin stiffness of wound tissue before and after LLLT using OCT and MyotonPRO.	1 year

Secondary

Measure	Time frame	Description
To compare wound skin stiffness with contralateral normal skin.	1 year	To assess differences in stiffness response between upper-body and lower-body wound sites. To determine the correlation between OCT and MyotonPRO stiffness measurements.

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026