Endophthalmitis, Intraocular Lymphoma, Masquerade Syndromes, Scleritis and Episcleritis, Uveitis
Conditions
Keywords
Uveitis, Scleritis, Masquerades syndromes, Intraocular lymphoma, Endophthalmitis
Brief summary
This is a retrospective study analyzing demographics, clinical characteristics, treatment received, and outcomes of ocular inflammatory diseases that presented to the Singapore National Eye Centre (SNEC).
Detailed description
This is a retrospective, cross-sectional study. In this study, the investigators aim to investigate demographics, clinical characteristics, treatment received, and outcomes of ocular inflammatory diseases, including masquerade syndromes such as ocular neoplasms (e.g., vitreoretinal and uveal lymphoma) and endophthalmitis that presented to the Singapore National Eye Centre (SNEC). Data on demographics, clinical features, diagnosis, investigations, secondary complications, treatment received, and outcomes will be analyzed using statistical software. The results of this study will lead to an improved clinical practice with better treatment selections and an optimized monitoring protocol for follow-up care for patients with ocular inflammatory diseases, including masquerade syndromes such as ocular neoplasms (e.g.,vitreoretinal and uveal lymphoma) and endophthalmitis. This will lead to better clinical outcomes and prevention of serious sight-threatening complications.
Interventions
OTHERNo Intervention: Observational Cohort
Not applicable, No intervention. Observational study.
Sponsors
Singapore National Eye Centre
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
21 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Patients diagnosed with uveitis * Patients diagnosed with scleritis or episcleritis * Patients diagnosed with ocular neoplasms e.g., vitreoretinal and uveal lymphoma * Patients diagnosed with endophthalmitis * Diagnosis confirmed by laboratory testing or histopathological examination * Patients diagnosed and managed at the Singapore National Eye Centre (SNEC)
Exclusion criteria
* Patients with less than two years of clinical follow-up * Patients with incomplete diagnostic confirmation (i.e., lacking laboratory or histopathological evidence) * Patients diagnosed outside of Singapore National Eye Centre (SNEC) * Cases with missing key clinical or outcome data
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Distribution of demographics, diagnosis, clinical features, treatment and outcomes | January 1987 and January 2025 | Percentage ethnic distribution, percentage of gender distribution, percentage of age distribution, percentage of etiology, percentage of clinical features, percentage of investigations, percentage of diagnosis, percentage of secondary complications, percentage of treatment received, percentage of outcomes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation of demographics, diagnosis, clinical features, and treatment outcomes | January 1987 and January 2025 | To evaluate the independent and combined effects of demographic factors, diagnostic categories, and clinical features on treatment outcomes using multivariate logistic and cox regression analysis |
Countries
Singapore
Outcome results
None listed