Type 2 Diabetes, Glycemic Response
Conditions
Keywords
Macronutrients, Type 2 Diabetes, Glycemic response, Exercise
Brief summary
The goal of this randomized crossover trial is to evaluate the impact of meal macronutrient composition on the glycemic response following exercise in males with type 2 diabetes. The main question it aims to answer is: • Is the consumption of a glucose enriched meal associated with a bigger reduction in plasma glucose following a 1-hour exercise session than other meals Researchers will compare different meal macronutrient composition to see how it affects the glycemic response after exercise. Participants will * Fast, then do a 1-hour exercise session * Eat a glucose enriched meal, then do a 1-hour exercise session * Eat a fructose enriched meal, then do a 1-hour exercise session * Eat a fat enriched meal, then do a 1-hour exercise session * Eat an aspartame enriched meal, then do a 1-hour exercise session
Detailed description
Meals The meals will be equivalent in terms of total calories (with the exception of the aspartame meal) and the percentage of protein will be the same in all four conditions. Only the fat and carbohydrates percentages will vary in the four meal conditions. Exercise protocol Each subject will perform a maximal aerobic capacity (VO2peak) test on an ergocycle at the start of the protocol. Subsequently, at one-week intervals, each patient will perform an exercise session consisting of one hour of ergocycle at a capacity corresponding to 60% of each individual's VO2peak. The prescribed workload will be established based on the VO2peak test. Exercise will be monitored using heart rate, work, and oxygen consumption measured using an indirect calorimetry system. The five conditions will be randomized and performed at one-week intervals. Each exercise session will be supervised by a physician. Patients taking oral hypoglycemic agents will not take their medication on the morning of the exercise. Blood samples Samples will be taken to measure glucose, free fatty acids, insulin, glucagon, and plasma catecholamines. In addition, an indirect calorimetry system will allow us to measure total substrate oxidation. For each blood sample period, there will be a 5-minute assessment as described above.
Interventions
DIETARY_SUPPLEMENTFasting
No meal
DIETARY_SUPPLEMENTSucrose enriched meal
175 ml of oatmeal cereal, one slice of bread, 30g of cheese, 22g sucrose
DIETARY_SUPPLEMENTFructose enriched meal
175 ml of oatmeal cereal, one slice of bread, 30g of cheese, 22g fructose
DIETARY_SUPPLEMENTFat enriched meal
175 ml of oatmeal cereal, one slice of bread, 30g of cheese, 15g fat
DIETARY_SUPPLEMENTAspartame enriched meal
175 ml of oatmeal cereal, one slice of bread, 30g of cheese, aspartame (matched for taste)
OTHERExercise session
A 60-minutes exercise session on a cycle ergometer (Corival 400, Quinton Instruments, Seattle, WA, USA) at 60% of the VO2peak (determined at a baseline visit)
Sponsors
Paul Poirier
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Intervention model description
Single-blind randomized crossover design with 5 conditions.
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Type 2 Diabetes * Oral hypoglycemic agents
Exclusion criteria
* Insulin * Other diabetes related medical complications or conditions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glycemic response during and following intervention | Plasma glucose and insulin levels from blood samples taken at -15, 0, 15, 30, 45, 60, 75 and 90 minutes from the beginning of the exercise. | Plasma glucose and insulin levels following consumption of different meal compositions and following a 1-hour exercise session. |
Countries
Canada
Outcome results
None listed