Catheter-related Bloodstream Infection, Intestinal Failure
Conditions
Brief summary
This retrospective cohort study aims to identify risk factors for catheter-related bloodstream infections (CRBSIs) in hospitalized patients with intestinal failure (IF), including all subtypes (Types I-III). The study included 321 patients with 9,365 catheter-days. Multivariate logistic and Cox regression analyses were used to identify independent risk factors. Stratified analyses identified subtype-specific risks, and hospital stay length and health economic outcomes were assessed. The study highlights the need for subtype-tailored prevention strategies and closer metabolic and immune monitoring in hospitalized IF patients.
Interventions
None listed
Sponsors
Jinling Hospital, China
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients meeting the ESPEN 2023 diagnostic criteria for intestinal failure.
Exclusion criteria
* Catheter indwelling duration \<48 hours; Implanted catheter before admission; Complex components in PN difficult to quantify; Positive blood cultures with unclear CRBSI diagnosis; Alternative infection sources identified.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| incidence rate of catheter-related bloodstream infection | From catheter insertion until removal or discharge, assessed up to 24 months. | frequency of catheter-related bloodstream infections occurring every 1,000 days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of lymphocytopenia | Baseline. | The proportion of patients with lymphocytopenia at baseline. |
| Proportion of patients with high parenteral nutrition energy supply | From catheter insertion until removal or discharge, assessed up to 24 months. | The proportion of patients whose average proportion of daily energy from PN to measured resting energy expenditure (PN/REE) exceeds 0.6 during the catheter indwelling period. |
| Proportion of patients with high calorie-to-nitrogen ratio | From catheter insertion until removal or discharge, assessed up to 24 months. | The proportion of patients receiving a parenteral nutrition formula with a non-protein calorie-to-nitrogen ratio (C/N ratio) equal to or greater than 100 kilocalories per gram of nitrogen (≥100 kcal/g N). |
| All-cause length of hospital stay | At the time of hospital discharge, assessed up to 24 months. | The total duration of hospitalization, measured in days, from admission to discharge. |
| Total hospitalization costs | At the time of hospital discharge, assessed up to 24 months. | The total direct medical costs (in CNY) incurred during the hospitalization. |
| Incidence of neutropenia | Baseline | The proportion of patients with neutropenia at baseline. |
Countries
China
Outcome results
None listed