High Risk of Death or Disability in Brain Hemorrhage: Role of Spot Sign and Secondary Markers

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07172542

Enrollment

Registered

2025-09-15

Start date

2025-10-15

Completion date

2026-05-15

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain Injuries, Cerebral Hemorrhage, Intracerebral Hemorrhage, Stroke

Brief summary

This study looks at patients with brain hemorrhage to see if a special sign on brain scans, called the Spot Sign, combined with other scan features, can predict a higher risk of death or disability. By comparing patient outcomes with existing prediction scores, the study aims to understand whether these scan markers provide extra value in identifying patients at higher risk.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* Spontaneous intracerebral hemorrhage confirmed by contrast-enhanced CT scan. * Follow-up CT scan performed within 24 to 48 hours. Non-inclusion Criteria : * Absence of initial contrast-enhanced CT or follow-up CT. * Hematoma due to trauma, epidural hematoma (EDH), subdural hematoma (SDH), or subarachnoid hemorrhage (SAH).

Exclusion criteria

* Patient deceased before the initial contrast-enhanced CT. * Major missing clinical data.

Design outcomes

Primary

Measure	Time frame
Hematoma Expansion within 48 Hours: Increase of more than 6 mL or over 30% between the initial CT and the follow-up CT (PREDICT study criterion) and/or Occurrence of Death Within the First Month	48 hours

Countries

France

Outcome results