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Pulmonary Function, Muscle Strength, and Functional Capacity in Minimally Invasive Cardiac Surgery

Evaluation of Pulmonary Function, Respiratory Muscle Strength, Peripheral Muscle Strength and Functional Capacity in Individuals Undergoing Minimally Invasive Cardiac Surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07172529
Enrollment
40
Registered
2025-09-15
Start date
2024-05-01
Completion date
2025-11-30
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Surgery, Functional Capacity, Muscle Weakness | Patient, Pulmonary Function

Keywords

cardiac surgery, muscle weakness, pulmonary function, kinesiophobia, functional capacity

Brief summary

The goal of this observational study is to evaluate pulmonary function, respiratory muscle strength, peripheral muscle strength, and functional capacity in adult patients undergoing either minimally invasive cardiac surgery (via mini-thoracotomy) or conventional sternotomy for coronary artery bypass grafting (CABG) at Gülhane Training and Research Hospital.The main questions it aims to answer are: Does minimally invasive cardiac surgery preserve pulmonary function better than conventional sternotomy? Does minimally invasive cardiac surgery result in less respiratory and peripheral muscle weakness compared to conventional sternotomy? Researchers will compare patients undergoing minimally invasive surgery with those undergoing conventional sternotomy to determine differences in pulmonary function, respiratory muscle strength, peripheral muscle strength, and functional capacity. Participants will: Undergo preoperative and postoperative (day 4) assessments including spirometry, inspiratory/expiratory mouth pressure measurements, and peripheral muscle strength testing (handgrip, shoulder flexion/abduction, hip flexion, knee extension). Perform functional capacity tests (30-second sit-to-stand test, 6-minute walk test). Complete questionnaires assessing pain (McGill Pain Questionnaire) and fear of movement (Tampa Scale of Kinesiophobia).

Detailed description

Coronary artery bypass grafting (CABG) is one of the most commonly performed surgical procedures for patients with complex coronary artery disease. While the standard approach is through median sternotomy, minimally invasive cardiac surgery performed via mini-thoracotomy has gained popularity due to potential benefits such as smaller incisions, reduced surgical trauma, lower risk of sternal complications, shorter hospital stays, and faster mobilization. However, its effects on pulmonary function, respiratory muscle strength, peripheral muscle strength, and functional capacity have not been sufficiently clarified. Postoperative pulmonary complications are a significant concern in cardiac surgery. Procedures involving cardiopulmonary bypass may result in atelectasis, pneumonia, pleural effusion, phrenic nerve injury, and diaphragm dysfunction. These complications can impair respiratory mechanics, delay rehabilitation, and increase morbidity and mortality. Therefore, identifying surgical approaches that better preserve pulmonary and muscular function is of great clinical importance. This observational study will prospectively evaluate adult patients undergoing CABG at Gülhane Training and Research Hospital, comparing two groups: those receiving minimally invasive cardiac surgery via mini-thoracotomy and those undergoing conventional sternotomy. The primary outcomes are changes in pulmonary function parameters measured by spirometry (FVC, FEV1, PEF) from baseline to postoperative day 4. Secondary outcomes include respiratory muscle strength (MIP, MEP), peripheral muscle strength (handgrip, shoulder flexion/abduction, hip flexion, knee extension), functional capacity (30-second sit-to-stand test, 6-minute walk test), pain intensity (McGill Pain Questionnaire), and fear of movement (Tampa Scale of Kinesiophobia). All assessments will be performed twice: before surgery (preoperative baseline) and on postoperative day 4. This time frame was chosen to capture early postoperative functional changes, which may influence short-term recovery and rehabilitation strategies. By comparing the two surgical techniques, this study aims to determine whether minimally invasive cardiac surgery provides better preservation of pulmonary and muscular function, ultimately supporting improved patient-centered outcomes and guiding clinical decision-making in surgical practice.

Interventions

None listed

Sponsors

Zehra Can Karahan
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

* Adults aged 18-80 years * Scheduled for elective cardiac surgery via either minimally invasive approach (mini-thoracotomy) or conventional sternotomy at Gülhane Training and Research Hospital * Able to provide written informed consent

Exclusion criteria

* Previous history of cardiac surgery * Presence of orthopedic or neurological disorders affecting mobility or muscle strength * Postoperative cerebrovascular event * Requirement for mechanical ventilation \> 24 hours postoperatively * Intensive care unit stay \> 48 hours

Design outcomes

Primary

MeasureTime frameDescription
Change in Functional Capacity - 6-Minute Walk DistanceBaseline to postoperative day 4Distance covered during the 6-minute walk test. Results will be reported in meters (m).
Change in Handgrip StrengthBaseline to postoperative day 4Handgrip strength measured with handheld dynamometer. Results will be reported in kilograms (kg).
Change in Functional Capacity - 30-Second Sit-to-Stand TestBaseline to postoperative day 4Number of repetitions performed during the 30-second sit-to-stand test. Results will be reported as number of repetitions.
Change in Knee Extension StrengthBaseline to postoperative day 4Knee extension strength measured with handheld dynamometer. Results will be reported in kilograms (kg).
Change in Pulmonary Function - Forced Vital Capacity (FVC)Baseline [preoperative] and postoperative day 4)Forced Vital Capacity measured by spirometry. Results will be reported in liters (L).
Change in Pulmonary Function - Forced Expiratory Volume in 1 second (FEV1)Baseline to postoperative day 4Forced Expiratory Volume in 1 second measured by spirometry. Results will be reported in liters (L).
Change in Respiratory Muscle Strength - Maximal Inspiratory Pressure (MIP)Baseline [preoperative] and postoperative day 4Inspiratory muscle strength measured with mouth pressure device. Results will be reported in cmH₂O.
Change in Respiratory Muscle Strength - Maximal Expiratory Pressure (MEP)Baseline [preoperative] and postoperative day 4Expiratory muscle strength measured with mouth pressure device. Results will be reported in cmH₂O.

Secondary

MeasureTime frameDescription
Change in Kinesiophobia - Tampa Scale of Kinesiophobia (TSK-17)Baseline and postoperative day 4Fear of movement assessed with the Tampa Scale of Kinesiophobia (TSK-17). Results will be reported as score values ranging from 17 to 68 (units on a scale).Higher scores indicate greater fear of movement (worse outcome).
Change in Pain Intensity - McGill Pain QuestionnaireBaseline and postoperative day 4Pain intensity assessed with the McGill Pain Questionnaire. Results will be reported as score values (units on a scale). Minimum score: 0 (no pain) Maximum score: 78 (maximum pain intensity) Higher scores indicate worse pain.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 16, 2026