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Comparing Relative Strengths of Statistical Associations Between Psychological Traits and Vaccination-Related Outcomes I

Improving Vaccine Outcomes in Older Adults-Quantitative

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07172074
Enrollment
1786
Registered
2025-09-15
Start date
2022-12-30
Completion date
2025-02-27
Last updated
2025-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Psychological Aspects, Vaccination, Vaccination Hesitancy, Vaccination Promotion

Keywords

Vaccination, Vaccine Confidence, Attitudinal Roots, Psychological Traits, Motivated Social Cognition

Brief summary

The goal of this study was to identify psychological motives that had the strongest statistical associations with vaccine outcomes in order to identify novel intervention targets to be used in vaccine promotion efforts. A national sample of US adults completed an online survey containing a variety of vaccine-related measures and psychological trait measures.

Detailed description

A national sample of US adults were recruited through Dynata, an online survey panel company, to complete an online survey. Participants completed a variety of vaccine-related survey items and an unprecedented number (\>20) of psychological trait measures. This was possible by using a Planned Missingness Design, where respondents only answer a predetermined subset of survey questions, which allows us to include more measures without significantly increasing the burden for participants. Participants were randomized to one of the three question blocks, where each block had a predetermined set of items that were roughly 1/3 of the items from each psychological trait measure. They were also randomized to complete questions that were about the psychological traits in general or about vaccines specifically.

Interventions

DIAGNOSTIC_TESTGeneral Psych Trait Measure

Respondents were randomized to answer whether psychological trait questions were general or about vaccines

OTHERVaccine-Specific Psych Trait Measures

Respondents were randomized to answer whether psychological trait questions were general or about vaccines

Sponsors

National Institute on Aging (NIA)
CollaboratorNIH
University of Iowa
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)

Masking description

Randomization was done by the online survey platform (Qualtrics)

Intervention model description

Decades of research has shown that information is sought out, evaluated, and used in a biased way in order to satisfy people's motivations to satisfy their psychological needs. This bias in information processing is broadly referred to as motivated social cognition. Three general psychological needs people are motivated to satisfy include: 1. Managing threats: Motivations to eliminate perceived physical, emotional, or ideological threats 2. Reducing uncertainty: Motivations to reduce uncertainty, complexity, ambiguity, or disorder 3. Achieving social goals: Motivations for relationships with like-minded others and keeping groups distinct I propose that different forms of these motives may underlie vaccine outcomes and the processing of vaccine-related information.

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Consent to participate * Agree to provide quality responses

Exclusion criteria

* Quota completed (Equal #s of respondents in each group) * Age group: 18-49, 50-64, 65+ * Race/ethnicity: Non-Hispanic White, Non-Hispanic Black, Hispanic * Income: \<$50K, $50K or more * Gender: Female, Male or other gender identity

Design outcomes

Primary

MeasureTime frameDescription
Vaccine attitudesDay 1Feelings towards vaccines on a 7-point scale, with Very negative (1) and Very positive (7) as the scale anchors
Vaccination HistoryDay 1Indicated if they had received up to 7 age-recommended vaccines (Response options: No, Yes, Don't know/Unsure)

Secondary

MeasureTime frameDescription
Psychological trait measuresDay 126 measures: Needle phobia, Disgust sensitivity, Distrust, Conspiratorial mindset, Medical ambiguity aversion, Open-minded thinking, Self-protection motivation, Psychological reactance, 7 Moral Foundations, Self-construal, Social dominance orientation, Misinformation susceptibility, Faith in intuition, Delay discounting, Outcome bias, Scientific knowledge, Subjective numeracy, Health literacy, Medical maximizing-minimizing, Emotional reactivity to rare events
7C Antecedents to VaccinationDay 1Single item to measure each antecedent to vaccination
Attitudes towards Complementary and Alternative MedicineDay 16 item measure
Personal Characteristics/DemographicsDay 116 characteristics: Gender, Age, Race/ethnicity, Income, State of residence, Zip code, Relationship status, Education, Work in medical field, Economic political ideology, Social political ideology, Political party affiliation strength, Religiosity, Religious ideology, Subjective health, Health conditions

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026