Prospective Observational Study to Compare REMS vs NEWS2 for Patients Presenting to the ED With Sepsis

Prospective Observational Study to Determine the Utility of REMS in Comparison to NEWS2 for Predicting Morbidity and Mortality Among Patients Presenting to the ED Suspicion of Sepsis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07171918

Enrollment

130

Registered

2025-09-15

Start date

2023-01-01

Completion date

2024-12-31

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Brief summary

Prospective observational study to determine the utility of Rapid Emergency Medicine Score (REMS) in comparison to National Early Warning Score2 (NEWS2) for predicting morbidity and mortality among patients presenting to the Emergency Department with clinical suspicion of Sepsis

Detailed description

Rapid Emergency Medicine Score (REMS) is an attenuated version of the Acute Physiology and Chronic Health Evaluation (APACHE) II score and has utility in predicting mortality in non- surgical patients. The NEWS2 can be used on all hospitalized patients to allow for the early detection of clinical deterioration and potential need for higher level of care. NEWS2 is closely associated with sepsis, however REMS is not so. But in recent studies comparing other EWS (Early Warning Scores) of sepsis, REMS was found to be superior. Hence comparing REMs against NEWS2 to determine prognostication value of both scores in sepsis.

Interventions

DRUGAntibiotics, Vasopressors

Both groups are scored on REMS and NEWS2, and then observed closely for the period of hospital stay with regard to ICU stay duration, ventilator days, vasopressor dependent days and total hospital duration

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* All patients presenting to ED of Tertiary Care Hospital in Thrissur. * Patients age \>/=18 years * Patients who give informed consent for participation in the study. * Suspicion of sepsis at the time of presentation to ED as per SSC Guidelines 2021

Exclusion criteria

* All patients with an alternate diagnosis other than sepsis at the time of discharge. * Patients referred from other hospitals with diagnosis of sepsis, after initiation of treatment

Design outcomes

Primary

Measure	Time frame	Description
To determine the utility of REMS score over NEWS2 score - number of days of intensive care.	18 months	To compare REMS score against NEWS2 score with regard to morbidity indicators as - Number of days of intensive care
To determine the utility of REMS score over NEWS2 score - need for vasopressor administration	18 months	To compare REMS score against NEWS2 score with regard to morbidity indicators as - need for vasopressor administration
To determine the utility of REMS score over NEWS2 score - number of days spent as IP	18 months	To compare REMS score against NEWS2 score with regard to morbidity indicators as - number of days spent in hospital
To determine the utility of REMS score over NEWS2 score - need for mechanical ventilation	18 months	To compare REMS score against NEWS2 score with regard to morbidity indicators as - need for mechanical ventilation

Secondary

Measure	Time frame	Description
To determine in- hospital mortality of patients with clinical suspicion of sepsis	30 days	To compare the effectiveness of REMS and NEWS2 in predicting the in-hospital, 30 day mortality of patients admitted with clinical suspicion of sepsis.
To determine the utility of REMS score over NEWS2 score of patients admitted with qSOFA >/=2	18 months	To compare the utility of REMS score over NEWS2 score for predicting the prognosis of patients admitted with qSOFA \>/= 2 ; serum lactates \>/= 2.

Countries

India

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026