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Treatment in Individuals With Rheumatoid Arthritis Who Have Temporomandibular Joint Dysfunction

The Effectiveness of Manual Therapy Applications in Individuals With Rheumatoid Arthritis Who Have Temporomandibular Joint Dysfunction

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07171671
Enrollment
57
Registered
2025-09-12
Start date
2024-10-01
Completion date
2025-08-26
Last updated
2025-09-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Manuel Therapy, Rheumatic Diseases, Temporomandibular Joint Dysfunction

Keywords

Rheumatoid arthritis, Temporomandibular joint dysfunction, Manual therapy, Pain

Brief summary

This study was conducted to investigate the effect of manual therapy applications on pain, range of motion and joint position sense in individuals with rheumatoid arthritis who have temporomandibular joint dysfunction. The 57 patients included in the study were divided into 3 groups by simple randomization. Group 1 received myofascial mobilization of masticatory muscles and group 2 received temporomandibular joint mobilization twice a week for 6 weeks. The control group received no treatment. The groups were evaluated twice, before and after treatment. The control group underwent a second evaluation 6 weeks after the first evaluation. C-ROM was used to evaluate cervical range of motion and joint position sensation, millimeter ruler was used to evaluate TMJ range of motion, Algometer was used to evaluate pressure pain threshold of muscles, Headache Impact Test-HIT-6 was used for headache, Fonseca Anamnestic Index (FAI) and Jaw Function Limitation Scale-20 (JFLS-20) were used for temporomandibular dysfunction severity, Generalized Anxiety Disorder-7 was used for emotional state. In the cervical range of motion, the myofascial group showed significant normal range of motion improvements only in the flexion and lateral flexion directions, while no benefit was obtained in the extension and rotation directions. In the joint mobilization group, significant improvements were observed in all directions (flexion, extension, lateral flexion, rotation) (p\<0.05). In the evaluation of cervical joint position sensation, improvements in joint position sensation were observed in all directions in the joint mobilization group. In the myofascial mobilization group, limited improvements were observed in some directions, but most of the variables decreased (p\<0.05). In the measurement of pressure pain thresholds, a decrease was observed in the two treatment groups before and after treatment and compared to the control group (p\<0.05), while no statistically significant difference was detected in any variable in the comparison between the treatment groups (P\>0.05). Patients in the two treatment groups showed an increase in mandibular range of motion in all directions compared to both the pre- and post-treatment and control groups (p\<0.05), while no statistically significant difference was detected in any variable in the comparison between the treatment groups (P\>0.05). Joint mobilization and myofascial mobilization applications significantly reduced headache, anxiety severity and improved jaw function. There was a significant decrease in HIT-6, GAD-7, JFLS-20 total, JFLS-20 mastication, JFLS-20 mobility, JFLS-20 communication and Fonseca scores in both groups (p\<0.05), while no statistically significant difference was found in any variable in the comparison of treatment groups (P\>0.05). It was observed that myofascial mobilization and joint mobilization applications had positive effects on pain, mandibular range of motion, cervical joint range of motion and joint position sensation, jaw functions, headache and anxiety level in individuals with rheumatoid arthritis with temporomandibular joint dysfunction.

Detailed description

This study was conducted to investigate the effect of manual therapy applications on pain, range of motion and joint position sense in individuals with rheumatoid arthritis who have temporomandibular joint dysfunction. The 57 patients included in the study were divided into 3 groups by simple randomization. Group 1 received myofascial mobilization of masticatory muscles and group 2 received temporomandibular joint mobilization twice a week for 6 weeks. The control group received no treatment. The groups were evaluated twice, before and after treatment. The control group underwent a second evaluation 6 weeks after the first evaluation. C-ROM was used to evaluate cervical range of motion and joint position sensation, millimeter ruler was used to evaluate TMJ range of motion, Algometer was used to evaluate pressure pain threshold of muscles, Headache Impact Test-HIT-6 was used for headache, Fonseca Anamnestic Index (FAI) and Jaw Function Limitation Scale-20 (JFLS-20) were used for temporomandibular dysfunction severity, Generalized Anxiety Disorder-7 was used for emotional state. In the cervical range of motion, the myofascial group showed significant normal range of motion improvements only in the flexion and lateral flexion directions, while no benefit was obtained in the extension and rotation directions. In the joint mobilization group, significant improvements were observed in all directions (flexion, extension, lateral flexion, rotation) (p\<0.05). In the evaluation of cervical joint position sensation, improvements in joint position sensation were observed in all directions in the joint mobilization group. In the myofascial mobilization group, limited improvements were observed in some directions, but most of the variables decreased (p\<0.05). In the measurement of pressure pain thresholds, a decrease was observed in the two treatment groups before and after treatment and compared to the control group (p\<0.05), while no statistically significant difference was detected in any variable in the comparison between the treatment groups (P\>0.05). Patients in the two treatment groups showed an increase in mandibular range of motion in all directions compared to both the pre- and post-treatment and control groups (p\<0.05), while no statistically significant difference was detected in any variable in the comparison between the treatment groups (P\>0.05). Joint mobilization and myofascial mobilization applications significantly reduced headache, anxiety severity and improved jaw function. There was a significant decrease in HIT-6, GAD-7, JFLS-20 total, JFLS-20 mastication, JFLS-20 mobility, JFLS-20 communication and Fonseca scores in both groups (p\<0.05), while no statistically significant difference was found in any variable in the comparison of treatment groups (P\>0.05). It was observed that myofascial mobilization and joint mobilization applications had positive effects on pain, mandibular range of motion, cervical joint range of motion and joint position sensation, jaw functions, headache and anxiety level in individuals with rheumatoid arthritis with temporomandibular joint dysfunction.

Interventions

OTHERexercises

manuel therapy and exercises

Sponsors

Sanko University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* Be aged between 18 and 65 * Have been diagnosed with rheumatoid arthritis according to the ACR/EULAR 2010 criteria * Be in the chronic phase of the disease * Have temporomandibular joint dysfunction according to the RDC/TMD criteria * Have intact cognitive functions * Individuals who agree to participate in the study and sign the informed consent form

Exclusion criteria

* \- Maksillofasiyal travma ve cerrahi öyküsü olanlar * Son 6 ayda ortodontik tedavi öyküsü olanlar * Trigeminal nevralji ve/veya fasiyal sinir paralizisi öyküsü olanlar * Romatoid Artrit dışında ek bir romatolojik hastalığı olanlar * Ağız içi splint kullanıyor olmak * Protez diş kullanımı ve molar dişlerde eksiklik * Servikal bölgeye ve temporomandibular eklem disfonksiyonuna yönelik son 6 ayda Manuel - Terapi, enjeksiyon vb. benzeri tedavi görmüş olmak

Design outcomes

Primary

MeasureTime frameDescription
assessing cervical joint range of motion and joint position sense6 weeksc-rom
TME Movement Clarity,6 weeksMillimetre Ruler
pressure pain threshold of muscles6 weeksAlgometer
headache6 weeksHeadache Impact Test- HIT-6
Severity of temporomandibular dysfunction6 weeksFonseca Anamnestik İndeksi ve Çene Fonksiyon Kısıtlanma Skalası-20(JFLS-20),

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 24, 2026