Post Operative Use of Neuromuscular Electrical Stimulation (NMES) Device for ACLR Patients

Effects on Patient Outcomes With Post-Operative Use of Zynex Neuromuscular Electrical Stimulation (NMES): Zynex-25

Status

Enrolling by invitation

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07171346

Enrollment

Registered

2025-09-12

Start date

2026-02-10

Completion date

2028-06-01

Last updated

2026-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ACL Injury, ACL Reconstruction, ACL Surgery, Electrotherapy, Muscle Atrophy or Weakness

Keywords

Electrotherapy, muscle strength, ACLR

Brief summary

This study is being conducted to learn about how neuromuscular electrical stimulation (NMES) in addition to standard of care aids in the recovery of muscle strength in patients undergoing ACLR procedure.

Detailed description

The addition of neuromuscular electrical stimulation (NMES) to standard ACLR rehabilitation has been demonstrated to improve knee extension and flexion compared to standard treatment only. NMES has also shown improved lower limb loading symmetry, walking velocity, stance time, cadence, maximum voluntary isometric contraction, motor unit behavior, muscle quality, and an increase in absolute muscle strength in functional tests compared to standard care of ACLR recovery. In this study we will be comparing bi-lateral presurgical and post surgical muscle strength symmetry in patients that follow the standard ACLR rehabilitation program and patients that use the NMES in addition to standard rehab.

Interventions

DEVICEZynex NexWave Electrotherapy Device

All participants will use the NMES device in addition to standard rehabilitation

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

15 Years to 50 Years

Healthy volunteers

Inclusion criteria

* ACLR surgical patients at KUMC sports medicine * 15 to 50 years old * BMI between 18 - 30 kg/m2 * No limitations impacting physical function within the last 6 months (not including the ACL injury)

Exclusion criteria

* Previous lower limb or spine injury involving surgical treatment * Prior spine surgery * Lower limb injury (other than ACL) preventing participation in physical activity for over two weeks in the past 6 months * Non english speaking * Vulnerable population, prisoner, or ward of the state

Design outcomes

Primary

Measure	Time frame	Description
Bilateral Muscle Symmetry Index	pre-operative to 3 months post-op	Comparing muscle size strength and function between operative and non-operative limbs

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 18, 2026