Blood Pressure, Body Composition, Dietary Analysis, TNF Alpha, Zinc Status
Conditions
Keywords
women of reproductive age, dietary assessment, hair zinc, TNF alpha, body composition, blood pressure, BOD POD
Brief summary
This study aims to determine the relationship between dietary patterns and hair zinc levels with body composition, tumor necrosis factor alpha (TNF-α), and blood pressure in women of reproductive age from different ethnic backgrounds in Jakarta, Indonesia (specifically Minangkabau, Sundanese, Javanese, Betawi, and Chinese). Participants are assessed once through dietary assessment, anthropometric measurements, and biological sample collection.
Detailed description
This cross-sectional observational study will evaluate dietary patterns and their association with nutritional status and inflammation in women of reproductive age. Participants will undergo dietary intake assessments (including the SQ-FFQ and a 3-day food diary), anthropometric and body composition measurements using the BOD POD (weight, height, fat mass, fat-free mass), and biospecimen sampling (blood and hair) for laboratory analysis of TNF-α and hair zinc concentrations. These findings are expected to offer information about dietary determinants and zinc micronutrient status that influence body composition, inflammation, and blood pressure in urban reproductive-age women from diverse ethnic backgrounds.
Interventions
OTHERNot applicable- observational study
This is an observational study; no interventions are administered to participants.
Sponsors
Indonesia University
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
19 Years to 49 Years
Healthy volunteers
Yes
Inclusion criteria
* Women aged 19-49 years * Residing in Jakarta for at least 6 months * Currently menstruating (not menopausal) * From Minangkabau, Sundanese, Javanese, Betawi, or Chinese ethnicity * Not pregnant or breastfeeding at the time of study
Exclusion criteria
* History of chronic diseases (e.g., diabetes, cardiovascular disease, cancer) * Currently on a medically prescribed diet or taking medication affecting nutrient status * Any condition interfering with accurate body composition measurement
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood Pressure | At baseline (single assessment) | Systolic and diastolic blood pressure are measured to assess cardiovascular health status |
| Dietary Zinc Intake | At baseline (single assessment) | Average daily zinc intake (mg/day) will be assessed using two dietary assessment methods: a Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ) and multiple-day Food Records. For women aged 19 to 49 years, the Recommended Dietary Allowance (RDA) is 8 mg/day, the Estimated Average Requirement (EAR) is 6.8 mg/day, and the Tolerable Upper Intake Level (UL) is 40 mg/day. Higher or lower values will be interpreted relative to these reference standards. |
| Diet Quality Assessed by HEI-2020 | Baseline (cross-sectional assessment at enrollment) | The Healthy Eating Index-2020 (HEI-2020) is a measure of diet quality that assesses conformance to the 2020-2025 Dietary Guidelines for Americans. The score ranges from 0 to 100, with higher scores indicating better adherence and higher diet quality. |
| Planetary Health Diet Index (PHDI) | Baseline (cross-sectional data collection) | The Planetary Health Diet (PHD), proposed by the EAT-Lancet Commission, is a dietary pattern designed to promote human health and environmental sustainability. The Planetary Health Diet Index (PHDI) is a scoring system (range: 0-150) that measures adherence to the PHD, with higher scores indicating greater adherence. |
| Ultra-Processed Food (UPF) intake | Baseline (cross-sectional data collection) | UPF intake will be estimated using the NOVA classification, expressed as percentage of total energy intake (%TEI). Higher percentages indicate worse outcome (poorer diet quality due to higher UPF intake). |
| Body Composition (Fat Mass, Fat-Free Mass) | At baseline (single assessment) | Measured using BOD POD to determine body fat percentage, fat mass, and fat-free mass |
| Hair Zinc Concentration | At baseline (single assessment) | Zinc concentration measured from hair samples as an indicator of long-term zinc status |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Inflammatory Biomarker Levels (TNF-α in Serum) | At baseline (single assessment) | Serum TNF-α measured as a marker of inflammation, assessed in approximately 30% of total participants (sub-sample) |
Countries
Indonesia
Contacts
Primary ContactDhani Latifani, BSc, MSc
Backup ContactAna D Sakinah, BApp.Sc
Outcome results
None listed