Cerebral Tumor
Conditions
Keywords
surgery, awake surgery, brain, brain tumor, brain area
Brief summary
This research project focuses on low-level cognitive functions such as perception (auditory, visual, etc.) and high-level cognitive functions (memory, language, temporal estimation, etc.). It aims to better understand the brain bases of these functions as well as their overlap (i.e., brain bases considered to be involved in different functions). To this end, various cognitive tasks will be performed before and during awake brain surgery, allowing us to determine the involvement of different areas in the task being performed. Comparing performance between the pre-test and the intraoperative test will help determine the potential involvement of the tested area.
Interventions
BEHAVIORALShort version of cognitive testing during surgery
Cognitive testing in 3 blocks of 3 minutes during awake surgery
Sponsors
University Hospital, Toulouse
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patients with a brain tumor * Aged 18 to 75 years * Signed informed consent * Vision that is corrected or adequate for the purposes of an experiment with visual stimuli * Hearing that is corrected or adequate for the purposes of an experiment with auditory stimuli * No known oculomotor disorder * Person affiliated with or benefiting from a social security scheme. * Free, informed, and written consent signed by the participant and the investigator (no later than the day of inclusion and before any examination required by the research)
Exclusion criteria
* Participants under protected status: guardianship, legal safeguard proceedings, or whose consent to participate in the experiment could be due to a severely altered psychological state, as determined by the medical team responsible for the surgery. * History of neurological disease affecting the central nervous system (Parkinson's, Alzheimer's, history of stroke or cerebral infarction) * Pregnant and/or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| development of an atlas mapping the brain regions involved in each major cognitive function | One day after the inclusion | Analysis of the percentage of yes responses during the intraoperative phase, taking into account the expected probability based on preoperative results. Preoperative performance data allows to determine an expected performance level during the intraoperative phase. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of tests | One day after the inclusion | number of tests for which a brain area is considered to be involved during the analysis of the primary criterion for the pre-per group |
| Location of brain tumors | one day after the inclusion | The MRI images of patients in the Pre-End group will be analyzed. It will be possible to determine whether their tumors overlap in a specific area, which could indicate that this area is essential for the process being studied. |
Countries
France
Contacts
Primary ContactFranck Emmanuel ROUX, PHD
Outcome results
None listed