CIRCAdian Rhythm of the IMMune Age IndeX (IMMAX)

CIRCAdian Rhythm of the IMMune Age IndeX (CIRCA-IMMAX) - Influence of Circadian Rhythm on the Determination of an Immune Age Metric

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07169721

Acronym

CIRCA-IMMAX

Enrollment

Registered

2025-09-12

Start date

2023-12-01

Completion date

2024-04-22

Last updated

2025-09-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Subjects, Immune Cells (Mucosal and Systemic)

Keywords

immune age

Brief summary

The goal of this observational study is to evaluate the influence of circadian rhythms on the determination of an individual's immune age. The biomarker IMMAX was calculated for 50 participants aged 20-69 at 8 a.m., 1 p.m. and 6 p.m. on the same day.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* aged \> 18 years * knowledge of German or English sufficient to provide verbal explanations and obtain written consent

Exclusion criteria

* exercise on the assessment day * acute infection * vaccination within the last 4 weeks * autoimmune disease * cancer * drugs that may influence immune cell counts * participation in other interventional studies during study period

Design outcomes

Primary

Measure	Time frame	Description
Changes in the Immune Age Index Immune Age Index (IMMAX) from morning to midday and evening	From 8 a.m. until 6 p.m. on the same day	To determine the Immune Age Index, 100 µl blood is collected and immunostained with antibodies. The immune cells are then analyzed using flow cytometry. IMMAX values range from 0 to 1 with higher values indicating a higher immune age.

Countries

Germany

Outcome results