Healthy Participants
Conditions
Brief summary
We aim to undertake the Global Reference Range Study (GRR) to establish a set of healthy adult reference values for measures of fibroinflammation, fat and size/volumes for the liver, and other abdominal and thoracic organs to assess, compare, and if necessary, propose ethnicity specific reference ranges for these measurements.
Interventions
None listed
Sponsors
Perspectum
National Heart Centre Singapore
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Male or female at least 18 years of age * Self-reported healthy * Willing and able to give informed consent for participation in the study * Willing and able to undergo an MRI
Exclusion criteria
* History of cardiovascular disease as follows: * Myocardial infarction * Heart failure * Cardiomyopathy * Stroke * Hospital admission/discharge for unstable angina * Heart surgery * Unstable angina * Transient ischemic attack * Presence of CVD risk factors such as hypertension, hyperlipidaemia, Type 2 diabetes, BMI \> 30 kg/m2, smoker (current/ex-smoker) * History of non-cardiac diseases related to the lungs, liver, kidneys, pancreas or spleen judged by the study investigator as therefore unsuitable to participate in the study * The participant may not enter the study if they have any contraindication to magnetic resonance imaging (standard MRI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the reference values for liver fibroinflammation in healthy adults from different ethnic groups. | 24 months |
Countries
Singapore
Contacts
CONTACTMasliza Mahmod
STUDY_CHAIRRavi Pattanshetty
Perspectum
Outcome results
None listed