Anticholinergic Syndrome, Frailty in Older Adults, Functional Decline
Conditions
Brief summary
This study investigates the anticholinergic burden on patients seen in the Subacute mobile outpatient geriatric clinic in Aalborg, Denmark, between the years of 2024 and 2025. The age demographic in Denmark and multiple other countries is changing rapidly, with more old and very old individuals as a result. As humans become older, they tend to accumulate more illnesses, and the risk of polypharmacy increases. There is a wide selection of medicine that affect the binding of acetylcholine to the muscarinic receptors, which is either the intended function of the pharmacological product or a side effect. Since there is no built-in feature in computer systems used by doctors to calculate the cumulative anticholinergic burden, it is often not recognized, thus not reflected upon. This raises concerns about potential central and peripheral side effects, such as altered mental status, visual disturbances, tachycardia, urinary and fecal retention, dry skin etc. The study aims to determine the prevalence of anticholinergics in the last 100 patients seen by the Subacute mobile outpatient geriatric clinic in Aalborg University Hospital. The patients are placed in municipal extended-care facilities. Furthermore, the study will investigate the prevalence of anticholinergic side effects concerning the burden on this population. The study is a retrospective chart review of patient charts from the years of 2024 and 2025, analyzing patient characteristics, comorbidities, medication lists, and calculating the anticholinergic burden through the ACB calculator.
Interventions
OTHERNo intervention as the study is observational
As this is an observation study, participants are not assigned an intervention as part of the study
Sponsors
Aalborg University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* patients seen by the Subacute outpatient geriatric clinic at Aalborg University hospital, Denmark, between 2024 and 2025. * Consecutive sampling starting with the most recent patient chart and going backwards. * Inclusion is based on chart review and all patients are therefore included consecutively.
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of anticholinergics | Day 1. That is on the day of patients first contact with the subacute outpatient geratric function at Aalborg Unviversity Hospital | Number of patients taking anticholinercis (yes/no) defined by the Anticholingeric Cognitive Burden scale (any score above 0) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of central side effects | On the day of patients first contact with the subacute outpatient geratric function at Aalborg Unviversity Hospital | Prevalence of any of the following conditions as described in patient charts: Delirium, other confusion, restlessness, hallucinations, Amnesia, dysarthria, ataxia, stupor, coma. |
| Prevalence of peripheral anticholinergic side effects | On the day of patients first contact with the subacute outpatient geratric function at Aalborg Unviversity Hospital | Prevalence of any of the following conditions as described in patient charts: Urinary retention, constipation, tachycardia, visual disturbances, dry skin, dry mouth. |
Countries
Denmark
Contacts
Primary ContactJohannes Riis, MD
Outcome results
None listed