Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation?

Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation? A Randomized Controlled Trial

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07165483

Enrollment

Registered

2025-09-10

Start date

2025-09-11

Completion date

2026-03-01

Last updated

2025-09-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dexmedetomidine, Intubation, Laryngoscopy, Stress Response, Time

Brief summary

This study aims to evaluate the effect of increasing preoperative timing of single dexmedetomidine on the stress response of laryngoscopy and intubation.

Detailed description

Maintaining hemodynamic stability during surgery is one of the most important tasks because good anesthesia increases the success rate of surgery and improves postoperative prognosis. Dexmedetomidine, a potent α2-adrenoreceptor agonist, produces not only a sedative-hypnotic effect, but in situations involving cardiac risk, it also produces analgesic effects and an autonomic blocking effect, by acting on a single type of receptor.

Interventions

DRUGDexmedetomidine

Patients will receive 0.5µg/kg dexmedetomidine (over 10 min) 20 min before induction of anesthesia then saline (over 10 min) 10 min before induction of anesthesia.

DRUGSaline

Patients will receive saline before induction of anesthesia as a control group.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Age from 18 to 65 years. * Both sexes. * American Society of Anesthesiology (ASA) physical status I-II.

Exclusion criteria

* Severe cardiovascular problems. * Respiratory disorders. * Diabetes. * Hypertension. * Obesity. * Allergic reaction to study drugs. * Patients on antihypertensive medication (α-methyldopa, clonidine, or other α2-adrenergic agonists) * Medications that affect heart rate (HR) or blood pressure (BP). * Pregnant. * Currently breast-feeding women. * History of sleep apnea. * Those for emergency procedures.

Design outcomes

Primary

Measure	Time frame	Description
Mean arterial pressure	Till the end of the surgery (Up to 2 hours)	Mean arterial pressure will be recorded at baseline, before induction, after induction, before intubation, after intubation, at 5 minutes, 10 minutes, 15 minutes, and then every 15 minutes until the end of surgery.

Secondary

Measure	Time frame	Description
Heart rate	Till the end of the surgery (Up to 2 hours)	Heart rate will be recorded at baseline, before induction, after induction, before intubation, after intubation, at 5 minutes, 10 minutes, 15 minutes, and then every 15 minutes until the end of surgery.
Need for intraoperative fentanyl	Intraoperatively	Need for intraoperative fentanyl will be recorded.
Incidence of adverse events	24 hours postoperatively	Incidence of adverse events such as bradycardia, hypotension, nausea, vomiting, respiratory depression, or any other complication.

Countries

Egypt

Contacts

Primary ContactMohammed S Elsharkawy, MD

mselsharkawy@med.tanta.edu.eg00201148207870

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026