Biofilm, Endothelial Dysfunction, Oral Bacteria, Periodontal Inflammation
Conditions
Brief summary
Periodontitis is a chronic inflammatory disease of the tooth-supporting tissues characterized by the constant interaction of microorganisms in subgingival plaque and host defense mechanisms. Periodontitis is considered a focus of infection caused by oral bacteria, bacterial byproducts, or inflammatory mediators that can interact with other parts of the body via the bloodstream.
Detailed description
Periodontitis is a chronic inflammatory disease of the tooth-supporting tissues characterized by the constant interaction of microorganisms in subgingival plaque and host defense mechanisms. Periodontitis is considered a focus of infection caused by oral bacteria, bacterial byproducts, or inflammatory mediators that can interact with other parts of the body via the bloodstream. Periodontal bacteria produce endotoxins in the form of lipopolysaccharide (LPS). Circulating LPS reacts with Toll-like receptors, promoting the production of reactive oxygen species and phagocytosis in the intima layer. Oxidative stress has been reported to be associated with mtDNA copy number.
Interventions
OTHERatheroma plaque
Before the endarterectomy procedure, samples will be collected for study from some of the atheroma plaques routinely taken for pathology from patients.
OTHERDental plaque
Subgingival plaque samples will be collected from patients before the endarterectomy procedure.
Sponsors
Istanbul Saglik Bilimleri University
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
25 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosed with endarterectomy * Not receiving chemotherapy * Not having received this treatment before
Exclusion criteria
* Having systemic infection * Patients with severe heart disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bacterial frequency (%) | Months 6-9 of the study | The percentage of bacteria in the red complex in atheroma plaque and dental plaque is evaluated using polymerase chain reaction methods. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in mtDNA copy number (number) | Months 6-9 of the study | Evaluation by means of quantitative polymerase chain reaction of mtDNA copy number in atheroma plaque |
| periodontal healths (mm) | 8 months | Evaluation by means of periodontal indices such as PI, GI, BOP, PD. |
Countries
Turkey (Türkiye)
Outcome results
None listed