Atrophic Mandible
Conditions
Brief summary
Background: Placement of implants in an atrophic posterior ridge is a challenge for so many clinicians. The success of dental implants depends on the volume of alveolar bone available to provide stability. Bone grafting using xenograft with PRF and e-PRF as a membrane has shown promising results in both bone healing and defect reconstruction. Aim of the study: to evaluate the effect of Platelet-rich fibrin (PRF) and Extended Platelet-rich fibrin (e-PRF) as a membrane with xenograft to increase the width of ridge in posterior mandible with simultaneous implant placement.
Interventions
OTHERe-PRF membrane will be used with xenograft simultaneously with implant placement.
Peripheral blood is collected in plain tubes and centrifuged (700-2000 g, 8 min) to separate plasma from red cells. The first 2-4 mL of platelet-poor plasma (PPP) is withdrawn and heated at 75 °C for 10 minutes to form albumin gel, then cooled for 1-2 minutes. Meanwhile, the remaining blood fractions (buffy coat, liquid PRF, red cells) are kept cooled to prevent premature clotting.
OTHERPRF membrane will be used with xenograft simultaneously with implant placement
Peripheral blood is collected in 9-10 mL additive-free tubes and centrifuged horizontally at 700-2000 g for 8 minutes.
Sponsors
Alexandria University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Patient with one or more missing posterior mandibular teeth. * Patient with atrophic posterior mandible with residual ridge width in the range of 4 to 6mm. * Patient with good oral hygiene and acceptable inter-arch space less than or equal to the restoration
Exclusion criteria
* The patient underwent alveolar ridge reconstruction in the same area. * Patients with immune diseases, uncontrolled hypertension, and uncontrolled diabetes. * Patient with any pathological condition at the site of surgery. * Heavy smoker, alcohol abuse, parafunctional habits.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in implant stability | baseline and 6 months | Osstell device will be used to measure the implant stability, primary stability Just after implant placement, and secondary stability 6 months from the time of implant placement. The measured values will be recorded in ISQ from 1 to 100, Implant stability is directly proportional to ISQ value |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change in pain scores | uo to 7 days | Visual Analogue Scale (VAS) will be used to assess pain for 7 days postoperatively using a 10-point (0-1= None, 2-4= Mild, 5-7= Moderate, 8-10= Severe) |
| Change in edema scores | up to 7 days | Assessment of edema will be done immediately, post-operative on the 2nd, 3rd, and 7th days as follows: no inflammation= none intraoral swelling confined to the surgical field = mild extraoral swelling in the surgical zone= moderate extraoral swelling spreading beyond the surgical zone= intense |
| change in bone width gain | baseline and 6 months | CBCT will be used |
| change in bone density | baseline and 6 months | CBCt will be used |
Countries
Egypt
Outcome results
None listed