Pressor Response
Conditions
Keywords
Preeclampsia, Nebulization
Brief summary
Dexmedetomidine nebulization in sever preeclamptic patients
Detailed description
Dexmedetomidine nebulization for attenuation of pressor response to laryngoscopy and endotracheal intubation in sever preeclamptic patients undergoing caesarean section under general anaesthesia. A prospective randomized clinical trial.
Interventions
DRUGSaline
Nebulization of normal saline
DRUGDexmedetomidine
Nebulization of dexmedetomidine
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Patients with severe pre-eclampsia scheduled for cesarean section under general anesthesia * ASA II, III
Exclusion criteria
* sever obesity (BMI ≥ 40) * Cardiac patients * History of diabetes mellitus * Renal dysfunction (elevated serum creatinine \> 2mg\\dl) * hepatic dysfunction (elevated hepatic enzyme three times above normal) * History to hypersensitivity to the tested drug. * Emergency surgery * Known fetal anomalies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Systolic blood pressure in response to endotracheal intubation | Intraoperative | the change in systolic blood pressure in response to endotracheal intubation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Optic nerve sheath diameter | Intraoperative | the change in optic nerve sheath diameter in response to endotracheal intubation |
| Incidence of maternal postoperative sore throat | 1 hour Postoperative | — |
| Incidence of maternal postoperative hoarseness of voice | 1 hour Postoperative | — |
Contacts
Primary ContactMohamed S. Hussein
Backup ContactFatma Nabil
Outcome results
None listed