Angiopoietin-like Protein-4, Endometriosis, Pelvic Pain
Conditions
Keywords
Endometriosis, Angiopoietin-like protein-4, Peritoneal fluid, Inflammation
Brief summary
Endometriosis is a chronic inflammatory disease associated with pelvic pain, dyspareunia, and impaired ovarian reserve. Cancer antigen-125 (CA-125) is widely studied but limited by low specificity, while angiopoietin-like protein-4 (ANGPTL4) has emerged as a potential biomarker due to its role in angiogenesis and inflammation. In the current study it was aimed to investigate serum and peritoneal fluid ANGPTL4 levels in women with endometriosis compared to healthy controls, and to evaluate their associations with clinical symptoms, serum CA-125, and anti-Müllerian hormone levels.
Interventions
OTHERAngiopoietin-like protein-4 (ANGPTL4) Peritoneal Fluid Level
Measurement of peritoneal fluid levels of Angiopoietin-like protein-4 (ANGPTL4) level by ELISA method.
OTHERCancer Antigen 125 (CA-125) Serum Level
Measurement of venous blood serum level of CA-125 level by ELISA method.
OTHERAngiopoietin-like protein-4 (ANGPTL4) Serum Level
Measurement of venous blood serum level of Angiopoietin-like protein-4 (ANGPTL4) Level level by ELISA method.
Sponsors
Ankara City Hospital Bilkent
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 44 Years
Healthy volunteers
Yes
Inclusion criteria
* Diagnosis of endometriosis for study group who underwent laparoscopic endometriosis surgery * Healthy women for control group
Exclusion criteria
* Cardiovascular diseases including hypertension * Type 1 or type 2 diabetes mellitus * Morbid obesity * Primary adrenal insufficiency * Uterine fibroids * Thyroid dysfunctions including Hashimoto thyroiditis and Grave's disease * Hepatic dysfunctions * Renal insufficiency * Genetic disorders in chromosome constitution or karyotype analysis including monosomy X, trisomy X and gene mutations as BMP15, FMR I, POFIB, and GDF9 * Neurologic diseases * Psychiatric disorders * Autoimmune diseases or syndromes including Addison's disease, autoimmune syndromes, scleroderma, Sjogren's syndrome, myasthenia gravis, inflammatory bowel diseases, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus and familial Mediterranean fever * History of any malignancy * History of exposure to chemotherapeutic agents or radiotherapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum and peritoneal fluid Angiopoietin-like protein-4 level | day 1 | Nanogram/milliliter |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum cancer antigen 125 level | day 1 | Unit/milliliter |
Countries
Turkey (Türkiye)
Outcome results
None listed