Air Pollution, Maternal Outcome, Pulmonary Arterial Hypertension
Conditions
Keywords
pulmonary hypertension, air pollution, maternal outcome, heart failure, preterm birth, low birth weight
Brief summary
With economic development and rapid urbanization, air pollution has become an increasingly severe public health concern. The risk of adverse pregnancy outcomes is significantly elevated for pregnant women complicated by pulmonary hypertension. However, no studies to date have specifically examined the impact of environmental factors on pulmonary hypertension in pregnant women, nor their subsequent birth outcomes. Therefore, investigating the correlation between them holds substantial clinical and public health significance.
Detailed description
The purpose of the research is preliminary found that the correlation between air pollution and maternal outcomes in pregnant women with pulmonary arterial hypertension and provide useful information for managment of pregnant women in special ambient conditions.
Interventions
None listed
Sponsors
Wei Huang
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Pregnant women with pulmonary hypertension who attended major medical centers included in this study from January 2013 to December 2022. * Complete medical records available; ② Pulmonary artery systolic pressure ≥ 35 mmHg by echocardiography or a confirmed diagnosis of pulmonary hypertension by right heart catheterization; ③ Residential address information available at the city (district, county) level or higher.
Exclusion criteria
* ① Unclear diagnosis and completely missing address information; * Incomplete medical records; ③ Lost to follow-up during pregnancy or within six weeks postpartum.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 1.main maternal outcome | diagnosis of pregnancy to six months postpartum | including maternal death and heart failure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Secondary maternal outcome events | From delivery to 42 days postpartum | including other cardiac events: arrhythmia requiring treatment, thromboembolic event, myocardial infarction, stroke, pulmonary hypertension crisis and so on. |
Other
| Measure | Time frame | Description |
|---|---|---|
| 2.main offspring events | From delivery to 42 days postpartum | including fetal or neonatal death, prematurity, low birth weight, small for gestational age |
Countries
China
Outcome results
None listed