Postural Mobilization Compared to Noradrenaline Only in Off-Pump CABG Surgery

Comparison of Hemodynamic Management by Postural Mobilization Versus Chemical Vasoconstriction Using Noradrenaline Exclusively in Off-pump Coronary Artery Bypass Graft Surgery: A Prospective, Randomized, Comparative, Single-center Study.

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07163858

Acronym

OPTICAB

Enrollment

Registered

2025-09-09

Start date

2025-10-06

Completion date

2027-08-31

Last updated

2025-12-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Bypass, Coronary Artery Disease(CAD), Coronary Artery Disease With Need for Bypass Surgery, Hemodynamic Management, Hemodynamic Optimization, Noradrenaline, Off Pump Coronary Artery Bypass Graft, Off Pump Coronary Artery Bypass Surgery

Keywords

open-heart coronary bypass, passive leg raising, hemodynamic management, off-pump CABG surgery

Brief summary

This interventional prospective randomized study is designed to compare hemodynamic management using postural mobilization (+/- noradrenaline) versus noradrenaline only in patients undergoing open-heart coronary artery bypass graft (CABG) surgery.

Detailed description

OPTICAB is a single-site study in France that aims to compare two hemodynamic management techniques during off-pump coronary artery bypass graft (CABG) surgery: postural mobilization (+/- noradrenaline) versus noradrenaline only. Primary objective is to evaluate how often noradrenaline is needed when managing hemodynamics using postural mobilization (passive leg raising) during off-pump CABG surgery. The study will also compare revascularization rate and post-operative complications among both groups, and assess perioperative hemodynamic management during the 30-day follow up period.

Interventions

PROCEDUREpassive leg raising for hemodynamic management during open-heart coronary bypass grafting

Passive leg raising will be used in the experimental group in order to manage hemodynamics: legs will be raised to an angle of approx. 45°

PROCEDUREUse of Noradrenaline only in control group

Noradrenaline will be used for hemodynamic management. Passive leg raising will not be used in this group

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Intervention model description

Single-site, prospective, interventional, single-blind randomized controlled trial

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adult patient * patient requiring isolated coronary bypass surgery * Elective procedure or medical emergency * First cardiac surgery * Patient with an EF ≥30% * Mandatory affiliation to a social security system * Signed informed consent form * Suspension of renin-angiotensin system inhibitors and angiontensn-neprilysin receptor blockers and sartans the day before surgical procedure

Exclusion criteria

* Contraindication to an inotropic substance (only NA will be used) * Contraindication to passive leg raising * Patient in a life-threatening emergency * History of cardiac surgery * Bilateral iliac or common femoral artery occlusion * EF \< 30% * Pregnancy and breastfeeding * Renal failure (GFR \< 40 ml/min/1.73 m²) * Patient with bilateral thigh amputation * Class III obesity BMI \> 40 kg/m²

Design outcomes

Primary

Measure	Time frame
Assess use of noradrenaline in the experimental group (postural mobilization) vs control group (NA only) for hemodynamic management during open-heart coronary bypass graft surgery.	From beginning to end of urgery

Countries

France

Contacts

Primary ContactSIESS

recherche-clinique@infirmerie-protestante.com+33 426297927

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026