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Neuromusculoskeletal Alterations After ACL Injury

Neuromusculoskeletal Alterations After ACL Injury: A Cross-Sectional Study of Cortical Activity, Motor Response, and Psychological Readiness

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07163468
Acronym
NEURO-ACL
Enrollment
60
Registered
2025-09-09
Start date
2025-06-01
Completion date
2025-08-01
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anterior Cruciate Ligament Injuries, Neurocognitive Function, Sports Injury

Keywords

Anterior Cruciate Ligament, Kinesiophobia, Electroencephalography

Brief summary

This study investigated how anterior cruciate ligament (ACL) injuries affect not only the knee joint but also brain activity, reaction speed, and psychological readiness to return to sports. A total of 60 male athletes, aged 18 to 30 years, were evaluated in three groups: healthy athletes, athletes who had undergone primary ACL reconstruction, and athletes who had undergone revision ACL reconstruction. The study measured brain activity with electroencephalography (EEG), reaction time with a computer-based test, and psychological status with standardized questionnaires. The findings showed that athletes with revision ACL surgery had more difficulties in attention control, slower reaction times, and greater psychological barriers compared to the other groups. These results suggest that ACL injuries and surgeries may influence not only physical recovery but also brain function and psychological readiness. The study highlights the importance of considering neuromuscular, cognitive, and emotional aspects when planning rehabilitation and return-to-sport decisions.

Interventions

None listed

Sponsors

Duzce University
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes

Inclusion criteria

Male athletes Age between 18 and 30 years Regular participation in amateur or professional sports Completion of ACL rehabilitation (for surgical groups) at least 6 months before enrollment Ability to undergo EEG and reaction time testing Provision of signed informed consent

Exclusion criteria

History of neurological or psychiatric conditions (e.g., epilepsy, ADHD, depression) Additional lower extremity injuries or orthopedic surgeries Metal implants or scalp conditions incompatible with EEG Uncorrected visual or auditory deficits Systemic illnesses (e.g., diabetes, multiple sclerosis, neuropathy) Use of psychoactive medication Any cognitive or physical limitation interfering with testing procedures Female participants (to avoid hormonal confounding effects on EEG recordings)

Design outcomes

Primary

MeasureTime frameDescription
Frontal EEG Theta/Beta RatioSingle assessment on the study day (June-July 2025)Cortical activity measured at F3 and F4 electrode sites using EEG (Nexus-10 system, Mind Media, Netherlands). Theta (4-8 Hz) and beta (13-21 Hz) power spectral densities were calculated and the ratio (theta/beta) was used as an indicator of attentional control. Higher ratios indicate reduced attention and cognitive efficiency.

Secondary

MeasureTime frameDescription
Visual Reaction Time (ms)Single assessment on the study day (June-July 2025)Computer-based visual response task; mean reaction time (ms) computed across 5 valid trials after practice. Longer times indicate lower sensorimotor efficiency.
Kinesiophobia (TSK-11 total score)Single assessment on the study day (June-July 2025)Tampa Scale of Kinesiophobia-11; 11 items, 1-4 Likert; total score 11-44. Higher scores indicate greater fear of movement/reinjury.
Psychological Readiness to Return to Sport (ACL-RSI total score)Single assessment on the study day (June-July 2025)ACL-RSI questionnaire; 12 items scored 0-100; total reported as mean (0-100). Higher scores indicate greater psychological readiness.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026