Fat Metabolism
Conditions
Keywords
exercise, exercise resistance, electrical stimulation
Brief summary
The study will find out if 100 minutes of electrical stimulation of muscle prevents the unfavorable consequence of insufficient exercise.
Detailed description
Exercise resistance is characterized by the absence of exercise induced improvements in fat metabolism following a meal, and results from prolonged sedentary behavior between successive workouts (i.e. 2+ sedentary days between exercise bouts). The suggested energy expenditure threshold for avoiding exercise resistance is the equivalent of walking \ 8,500 steps/day. However, population data indicate that the typical adult in the US only walks 5,000 steps/day (i.e. 3,500 steps below the threshold). Neuromuscular Electrical Stimulation (NMES) evokes skeletal muscle contractions and increases energy expenditure. The hypothesis to be explored in this current proposal is: NMES will prevent exercise resistance. The plan is to induce exercise resistance via short-term abstention from activity other than exercise, and then on a separate occasion, use NMES to prevent exercise resistance (i.e. the short-term abstention from exercise will be "replaced" with NMES).
Interventions
OTHERneuromuscular electrical stimulation
The study participants will engage in 100-minutes of neuromuscular electrical stimulation (NMES). NMES pads are sticky pieces of plastic, similar in size to a 25-cent coin. The pads will be placed on the bellies of thigh muscles (the vastus lateralis, vastus medialis), and calf muscles (the long and short head of the gastrocnemius). These skeletal muscles are selected due to their size (thereby promoting a bigger increase for metabolic rate compared with a small muscle), because they are relatively superficial, and because previous published studies of NMES used these anatomical locations.
Sponsors
Colorado State University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Regularly active (more than 30 minutes of exercise per day, 3 days per week, over the previous 12 months) * Ability to complete at least one hour of treadmill exercise (i.e. jogging/running), * Willing to abstain from caffeine and alcohol for 24-hours prior to three different study visits * Competency in English
Exclusion criteria
* Current or previous injuries that may hinder a participant's ability to exercise on a treadmill * A history of cardiopulmonary disorder that may be contra-indicative to treadmill exercise * Current use of cardio-pulmonary medication to treat a cardio-pulmonary condition * Currently breastfeeding * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fat oxidation | Blood will be sampled and triglyceride concentration measured. Study participants will eat a meal. Blood will be sampled and triglyceride concentration measured every 30-minutes for 4 hours. | Circulating triglyceride concentration after eating a high fat meal. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORChristopher Bell, Ph.D.
Colorado State University
Outcome results
None listed