Nerve Excitation Sensitivity
Conditions
Keywords
Peripheral nerve stimulation, Magnetic and electric stimulation, Sensitivity of nerves to magnetic fields
Brief summary
Volunteers will undergo various peripheral nerve stimulations (electric, electromagnetic, and temporal interference) to evaluate each method's sensitivity. The main objective is to examine the relationship between nerve activation and coil placement relative to the nerve, as well as how different coil types influence maximal nerve activation.
Interventions
DEVICEElectric and electromagnetic stimulation
Application of electromagnetic and electric stimulation using coils of different designs and electrodes to assess peripheral nerve sensitivity. The stimulation is momentary, non-therapeutic, and performed for basic science research purposes
Sponsors
Bern University of Applied Sciences
Swiss Paraplegic Research, Nottwil
Thomas Niederhauser
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Person aged \> 18 years * Signed informed consent * Healthy * Willingness and ability to adhere to study procedures
Exclusion criteria
* Known hypersensitivity to electric or electromagnetic stimulation * Any implanted metal or electronic device in the upper body (except dental work such as fillings or braces), e.g., active medical devices, metal implants * Neurological or neuromuscular disorders or conditions * History of seizures or epilepsy * Current treatment with drugs that lower seizure threshold (e.g., certain analgesics, methylxanthines, antipsychotics, antidepressants, antiepileptics, anesthetics) * Pregnancy or breastfeeding * Surgical intervention of the arm within the last 4 weeks * Allergy to adhesives or ultrasound gel components (e.g., polyethylene glycols) * Skin lesions, infections, or strictures in the arm region * Tattoos on the stimulated (right) arm and hand, or in any area likely to be captured in video recordings * Inability to follow study procedures (e.g., due to language barrier, psychological disorders, dementia) * Participant deprived of liberty by administrative or judicial decision or under legal guardianship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maximum nerve activation response to electromagnetic stimulation with different coils | Day 1 | Maximum of the measured signals (muscle contraction from electromyography (EMG) and finger movement from accelerometer) obtained across all stimulation positions at a given stimulation intensity for each coil type. This reflects the relative sensitivity of peripheral nerves to electromagnetic stimulation with different coil designs. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Spatial range of nerve activation with electromagnetic coils | Day 1 | Distance around the stimulation position yielding the maximum response (E1), within which the measured signals (muscle contraction and finger movement) remain at least 50% of the maximum, across all coil positions at a given stimulation intensity. |
| Spatial range of nerve activation with neuromuscular electrical stimulation electrodes (NMES) | Day 1 | Distance around the stimulation position yielding the maximum response, within which the measured signals (muscle contraction and finger movement) remain at least 50% of the maximum, across all NMES electrode positions at a given stimulation intensity. |
| Amplitude ratios of temporal interference stimulation (TIS) electrodes associated with nerve activation | Day 1 | Electrode amplitude ratios during Temporal Interference Stimulation (TIS) for which measured signals remain at least 50% of the maximum signals observed at the optimal position. |
Countries
Switzerland
Contacts
Primary ContactThomas Niederhauser, PhD
Outcome results
None listed