Cannabis Dependence, Harmful Use, Cognitive Assessment
Conditions
Keywords
Cannabis Dependence, Cannabis Use Disorder, Abstinence, Cognitive Function, Disorder; Abstinence; Cognitive Function; Neuropsychological
Brief summary
Cannabis Abstinence and Neurocognitive Assessment in Adolescence
Detailed description
Evaluate the development of cognitive functions following attainment of abstinence in a group of adolescents with cannabis dependence or harmful cannabis use. Abstinence is confirmed by toxicological testing.
Interventions
DIAGNOSTIC_TESTNeurocognitive assessment
Neurocognitive battery: TMT-Trail Making Test Auditory Verbal Learning Test Stroop Test Tower of London (ToL), Shallice version Continuous Performance Test-Identical Pairs Other psychometrics: The level of dependence is quantified using the CAST (Cannabis Abuse Screening Test)
DIAGNOSTIC_TESTUrine toxicological assessment
Urine toxicological assessment
Sponsors
University Hospital Pilsen
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Adolescents aged 15-18 years with a diagnosis of cannabis dependence or harmful cannabis use.
Exclusion criteria
* psychiatric comorbidity - Dual diagnosis, including psychotic disorders, mood disorders, severe organic brain damage, or autism spectrum disorder, with the exception of compensated and stabilized anxiety disorder. Psychopharmacological treatment is permitted, except for antipsychotics prescribed for psychosis. * somatic comorbidity - Severe endocrine disorders such as diabetes mellitus, thyroid dysfunction, or severe cardiovascular disease. * Violation of abstinence between the first and second neuropsychological assessments, as well as severe decompensation of mental state requiring modification of established psychopharmacological treatment.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in performance TMT-B | 8 weeks | Change in performance on the Trail Making Test - Part B (TMT-B) \[Time Frame: after 8 weeks of abstinence from cannabis\] |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in performance on AVLT | 8 weeks | Change in performance on the Auditory Verbal Learning Test (AVLT) \[Time Frame: after 8 weeks of abstinence\] |
| Change in performance on the Stroop Test | 8 weeks | Change in performance on the Stroop Test \[Time Frame: after 8 weeks of abstinence\] |
| Change in performance on the Tower of London | 8 weeks | Change in performance on the Tower of London (Shallice version) \[Time Frame: after 8 weeks of abstinence\] |
| Change in performance on CPT-IP | 8 weeks | Change in performance on the Continuous Performance Test - Identical Pairs (CPT-IP) \[Time Frame: after 8 weeks of abstinence\] |
Other
| Measure | Time frame | Description |
|---|---|---|
| Cannabis Abuse Screening Test versus degree of neurocognitive impairment | 8 weeks | Correlation between severity of cannabis dependence (Cannabis Abuse Screening Test, CAST) and degree of neurocognitive impairment \[Time Frame: baseline and after 8 weeks of abstinence\] |
Countries
Czechia
Contacts
Primary ContactJiri Podlipny, MD, Ph.D.
Backup ContactFrantisek Nekvapil, MD
Outcome results
None listed