Effect of Argon Laser Panretinal Photocoagulation on Corneal Endothelial Cell Density .

Effect of Argon Laser Panretinal Photocoagulation on Corneal Endothelial Cell Density Among Patients With Proliferative Diabetic Retinopathy .

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07157553

Enrollment

Registered

2025-09-05

Start date

2025-10-01

Completion date

2027-12-30

Last updated

2025-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Panretinal Photocoagulation

Keywords

panretinal photocoagulation, corneal endothelial cell density

Brief summary

This study investigates the effect of argon laser panretinal photocoagulation (PRP) on the corneal endothelial cell density (ECD) in patients with proliferative diabetic retinopathy (PDR) by comparing ECD measurements before and after PRP treatment.

Detailed description

Proliferative diabetic retinopathy (PDR) is characterized by abnormal neovascularization driven by ischemic retinal tissue hypoxia and elevated vascular endothelial growth factor (VEGF) levels. Argon laser retinal photocoagulation (ALRP) is a standard treatment that applies thermal damage to the retinal pigment epithelium, reducing retinal oxygen demand and VEGF production, thereby causing regression of neovascular vessels. However, the laser light must pass through the anterior eye structures, potentially causing thermal and inflammatory damage to tissues such as the corneal endothelium, which is crucial for maintaining corneal transparency. This prospective observational clinical study conducted at Assuit University Hospital evaluates the impact of ALRP on corneal endothelial cell density using specular microscopy before, 1 week, and 1 month after PRP treatment in newly diagnosed PDR patients. Secondary outcomes include changes in cell morphology such as hexagonality and coefficient of variation, indicative of endothelial cell health and stability.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Patients from either sex with any age newly diagnosed PDR requring PRP .

Exclusion criteria

* history of corneal disease * previous intraocular surgery * glaucoma or intraocuar inflamation .

Design outcomes

Primary

Measure	Time frame	Description
Change in Corneal Endothelial Cell Density (ECD) after PRP	baseline	The primary outcome is the quantitative change in the corneal endothelial cell density measured by specular microscopy, comparing pre-treatment baseline values with post-treatment values at 1 week and 1 month intervals. This measure reflects the potential impact of ALRP on the corneal endothelial integrity, crucial for corneal transparency and function.

Outcome results