Evaluation of Thyroid Function, Lipid Profile, and Uric Acid Levels in Hemodialysis Patients

Evaluation of Thyroid Function, Lipid Profile, and Uric Acid Levels in Patients Undergoing Hemodialysis Prevalence in Assiut University Hospital

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07157267

Enrollment

100

Registered

2025-09-05

Start date

2026-07-01

Completion date

2027-12-30

Last updated

2025-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elevated Uric Acid, Hemodialysis, Thyroid Dysfunction

Keywords

hemodialysis, elevated uric acid, Thyroid Function Status

Brief summary

This observational study evaluates the prevalence and relationships of thyroid dysfunction, lipid abnormalities, and elevated uric acid levels in adult patients undergoing maintenance hemodialysis at Assiut University Hospital.

Detailed description

Chronic kidney disease (CKD) patients on maintenance hemodialysis frequently experience metabolic disturbances including thyroid hormone imbalances, dyslipidemia, and hyperuricemia, which heighten cardiovascular risk. This prospective cross-sectional study aims to investigate the prevalence and interrelations of thyroid function abnormalities (measured via serum TSH, Free T3, Free T4), lipid disorders (total cholesterol, HDL-C, LDL-C, triglycerides), and serum uric acid levels in a cohort of 100 adult patients undergoing regular hemodialysis for at least three months at Assiut University Hospital. Data will be collected through questionnaires, clinical exams, ultrasound thyroid scanning, and detailed laboratory and dialysis records review. The study also examines correlations between these biochemical parameters and patients' demographic and clinical characteristics, such as age, gender, smoking status, dialysis duration/frequency, and comorbidities like diabetes mellitus and hypertension. Statistical analyses using SPSS will identify the prevalence of metabolic alterations and their clinical implications in this vulnerable population.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adults ≥18 years * On regular hemodialysis for ≥3 months

Exclusion criteria

* On lipid-lowering or uric acid-lowering medications * Acute infections or hospitalizations in the past month

Design outcomes

Primary

Measure	Time frame	Description
Thyroid Function Status	baseline	Assessment of the prevalence and types of thyroid dysfunction in hemodialysis patients

Outcome results