Perioperative Outcomes for Children With Preoperative URTI Symptoms After COVID-19 Pandemic

Perioperative Outcomes for Children With Preoperative Upper Respiratory Tract Infection Symptoms in Elective Non-cardiac Surgery After COVID-19 Pandemic at a Large Tertiary Hospital in China: a Retrospective Cohort Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07157111

Acronym

URTI

Enrollment

2392

Registered

2025-09-05

Start date

2025-09-01

Completion date

2025-10-10

Last updated

2025-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID - 19, Elective Non-cardiac Surgery, Perioperative Respiratory Adverse Events, Postoperative Complications, URTI

Brief summary

The goal of this observational study is to investigate the impact of the COVID-19 pandemic on perioperative outcomes in children with preoperative URTI symptoms and to explore whether the COVID-19 pandemic affected the additional surgical risk associated with preoperative URTI symptoms. The main question it aims to answer is the appropriate timing of elective non-cardiac surgery in the post-COVID-19 era.

Detailed description

This study aims to investigate the impact of the COVID-19 pandemic on perioperative outcomes in children with preoperative URTI symptoms and to explore whether the COVID-19 pandemic affected the additional surgical risk associated with preoperative URTI symptoms. The findings will provide evidence-based guidance for optimizing surgical timing decisions in the post-COVID-19 era.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Years to 12 Years

Healthy volunteers

Inclusion criteria

* Aged 0-12 years * ASA physical status classification I-III * Undergoing non-cardiac surgery * Children presenting with mild URTI symptoms within 2 weeks before surgery

Exclusion criteria

* Presenting with severe underlying diseases (e.g., congenital heart disease, immunodeficiency) * Presenting with a single symptom of fever that can be explained by other diseases * Day surgery * Children with abnormal preoperative chest X-rays

Design outcomes

Primary

Measure	Time frame	Description
postoperative complications	7days	The postoperative complications including hemorrhage, infection, gastrointestinal complications, respiratory adverse events (RAE), and recurrence of the primary disease.

Secondary

Measure	Time frame	Description
Total hospital length of stay	10days	Total hospital length of stay
Intraoperative RAE	1day	Intraoperative RAE, including hypercapnia, hypoxemia
Emergence RAE	1day	Emergence RAE, including hypercapnia, hypoxemia
PACU stay	1hour	Meeting discharge criteria from PACU
Postoperative length of stay	7days	Postoperative hospital length of stay

Countries

China

Outcome results