Facial Skin Aging and Dullness
Conditions
Brief summary
This study aims to evaluate the anti-aging and skin tone improvement effects of two facial serums over a 12-week period. It was conducted at a single research center with a 2-week washout period followed by full-face application of the test products for 12 weeks. A total of at least 120 healthy Chinese female participants aged 18 to 45 were enrolled and divided into two treatment groups:Each group included both early aging (18-29 years) and mature aging (30-45 years) subgroups, with at least 30 participants in each subgroup.
Interventions
OTHERSerum 1
Applied topically on the full face in the morning and evening for 12 weeks during the treatment period. Used by participants in the Serum 1 group.
OTHERSerum 2
Applied topically on the full face in the morning and evening for 12 weeks during the treatment period. Used by participants in the Serum 2 group.
Sponsors
ChinaNorm
Study design
Allocation
NA
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Participants were assigned in parallel to one of two serum groups (Serum 1 or Serum 2), based on stratification by aging type (early aging or mature aging). The products were applied twice daily over 12 weeks.
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
1. Chinese female aged 18-45 years (evenly split among Early aging \[18-29 years\] and Mature aging \[30-45 years\]). 2. All skin types (dry, normal, oily, or mixed). 3. Currently experiencing lack of radiance, roughness, dullness, and fine lines or wrinkles on facial skin as self-claimed. 4. Early aging group (18-29 years): Must present with corresponding severity for the attributes evaluated by Dermatologist, including: * Skin smoothness, radiance, dullness: grade between 2 and 6 (scale 0-9); * Size of acne marks (PIH): size ≥ 2; * Small folds on nasolabial zone: grade between 1 and 3 (Skin Aging Atlas, 0-6 scale, Page 56-57). 5. Mature aging group (30-45 years): Must present with corresponding severity for the attributes evaluated by Dermatologist, including: * Skin smoothness, radiance, dullness: grade between 4 and 6 (scale 0-9); * Small folds on nasolabial zone: grade between 1 and 4 (Skin Aging Atlas, 0-6 scale, Page 56-57); * Forehead wrinkles: grade ≥ 2 (Skin Aging Atlas, 0-8 scale, Page 32-33); * Crow's feet wrinkles: grade ≥ 2 (Skin Aging Atlas, 0-6 scale, Page 40-41). 6. Regular user of serum and sunscreen products. 7. Did not participate in any clinical test or cosmetic product test on skin within the last 3 months. 8. No exclusion by dermatologist due to other medical or dermatological reasons. 9. In general good health at the time of the study. 10. Willing and able to participate as evidenced by signing of informed consent and photo release form. 11. Must be willing to comply with all study protocol requirements (including using only the skincare products provided during the study and not taking topical or oral treatments such as retinol, hormones, or antioxidant health supplements).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Dermatologist-Assessed Wrinkle Attributes | from Baseline to Week 12 | Crow's feet wrinkles, forehead wrinkles, global wrinkles, small folds on nasolabial zone and global fine lines will be evaluated by dermatologist. |
| Self-assessment Questionnaire | 12 weeks | Participants will complete a 5-point self-assessment questionnaire at Timm, T4w, T8w, and T12w, evaluating their perception of skin softness, smoothness, plumpness, elasticity, hydration, oil control, and visible aging signs. Ratings from 4 to 5 will be used to calculate Top 2 box percentage. |
| Change in Dermatologist-Assessed Skin Texture and Quality Attributes | from Baseline to Week 12 | Skin smoothness (visual), skin elasticity, skin softness, skin firmness, skin plumpness, cheek pores will be evaluated by dermatologist. |
| Change in Dermatologist-Assessed Skin Tone Attributes | from Baseline to Week 12 | Skin radiance, skin translucency, skin pigmentation, skin fairness, skin tone evenness and skin dullness will be evaluated by dermatologist. |
Secondary
| Measure | Time frame |
|---|---|
| Change in Skin Hydration Measured by Corneometer | 12 weeks |
| Change in Cheek Skin Surface Condition Using VisioScan VC20 | 12 weeks |
| Change in Skin Elasticity Measured by Cutometer | 12 weeks |
| Change in Transepidermal Water Loss (TEWL) Measured by Vapometer | 12 weeks |
| Change in Facial Image-Based Skin Parameters Using VISIA-CR | 12 weeks |
Countries
China
Outcome results
None listed