Refractory Cardiac Arrest
Conditions
Keywords
cardiac arrest
Brief summary
This is a single Center interventional study, assessing the feasibility of a complex treatment strategy where an in-hospital standard care process is applied in an out-of-hospital cardiac arrest. The objective of this study is to investigate the feasibility of a prehospital eCPR program in the context of the Pavia province in order to reduce the time from cardiac arrest to organ reperfusion with thefarthest aim of improving survival and good neurologic outcomes of patient victims of refractory cardiac arrest.
Interventions
The intervention of this study consists of moving the current eCPR program out of the hospital to reduce the time from collapse to ECMO flow (low-flow time).
Sponsors
Fondazione IRCCS Policlinico San Matteo di Pavia
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* out-of-hospital cardiac arrest occurred in Pavia province * the age of the patient is between 18 and 70 * witnessed cardiac arrest * CPR started within 5 minutes of the patient's collapse or presence of gasping at the arrival of the ACLS team * eCPR team arrived within 60 minutes of the patient's collapse * etCO2 ≥ 10 mmHg * mechanical chest compression is ongoing * refractory cardiac arrest after at least 15 minutes of ACLS
Exclusion criteria
* Modified Rankin Scale (mRS) ≥ 3 * Advanced COPD or other advanced pulmonary illness * End-stage or metastatic neoplasm
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| number of successful eCPR placed in prehospital settings over patients that meet inclusion criteria | up to 12 months | Successful cannulation is described as maintaining an ECMO circulatory flow of 40 ml/kg/min or more for at least 5 minutes. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cause of cannulation failure | up to 12 months | — |
| Proportion of cannulation feasibility according to the implant site | up to 12 months | — |
| Evaluation of eCPR Team Performance | up to 12 months | Evaluation of eCPR Team Performance to better design a definitive institutional eCPR program |
Countries
Italy
Contacts
Primary ContactAlessandra Palo, MD
Outcome results
None listed