Adapted High-Intensity Virtual Reality Exergaming

Feasibility of Vigorous Extended Reality Exergaming on Cardiometabolic Health in Youth With Mobility Disabilities: A Case Series

Status

Completed

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07155213

Enrollment

Registered

2025-09-04

Start date

2025-09-03

Completion date

2026-04-01

Last updated

2026-04-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral Palsy

Keywords

active video gaming, telehealth, telerehabilitation

Brief summary

This study will test the acceptability and benefits of a home-based high-intensity virtual reality exercise program for young people with physical disabilities. The program will last 6 weeks. There will be a total of two visits to the laboratory for exercise-related health assessments. The program includes head-mounted displays (Meta Quest) and off-the-shelf games.

Interventions

BEHAVIORALVirtual reality exergaming

High-intensity active video gaming using head-mounted display.

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Intervention model description

Virtual reality high-intensity exercise in either the seated or standing position.

Eligibility

Sex/Gender

ALL

Age

13 Years to 25 Years

Healthy volunteers

Inclusion criteria

* overweight or obese (based on CDC body mass index normative ranges for age and sex) * physically inactive (\<150 min/week of moderate exercise) * Gross Motor Function Classification System level (GMFCS) levels I-IV * Physician clearance to participate * Wifi internet access at home

Exclusion criteria

* Complete blindness or deafness * GMFCS level V * Unable to communicate in English * Prone to photosensitive seizures * Pregnant (due to radiation from a Dual Energy X-ray Absorptiometry \[DXA\] scan

Design outcomes

Primary

Measure	Time frame	Description
Total lean mass	week 0, week 7	lbs
Total fat mass	Week 0, Week 7	lbs
Systolic blood pressure	Week 0, week 7	mmHg
high sensitivity C-reactive protein (hsCRP)	Week 0, Week 7	mg/L
hemoglobin A1c (HbA1C)	Week 0, week 7	mmol/mol
fasting insulin	Week 0, week 7	μIU/mL
Total cholesterol	Week 0, week 7	mg/dL
Low-density lipoprotein	Week 0, week 7	mg/dL
High-density lipoprotein	Week 0, week 7	mg/dL
Diastolic blood pressure	Week 0, week 7	mmHg

Secondary

Measure	Time frame	Description
Peak oxygen consumption (pVO2)	Week 0, Week 7	mlkg/min
Total work output	Week 0, Week 7	watts
Resting heart rate	Week 0, week 7	beats/min

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 14, 2026