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Ophthalmic Diseases and AI: an RCT Study

Ophthalmic Diseases and AI: an Parallel Comparison RCT Study

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07154680
Enrollment
2000
Registered
2025-09-04
Start date
2024-08-15
Completion date
2025-01-30
Last updated
2025-09-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eye Diseases

Brief summary

Ophthalmic diseases are a major category of conditions affecting visual health, including but not limited to cataracts, glaucoma, retinal and choroidal diseases, and refractive errors (such as myopia, hyperopia, and astigmatism). With the advancement of technology, artificial intelligence (AI) is being increasingly applied in the field of ophthalmology. This clinical trial aims to evaluate the potential of large language models (LLMs) in ophthalmology. The main questions to be addressed are: 1. Assessing the effectiveness of large language models (LLMs) in the diagnosis and treatment of ophthalmic diseases: Through randomized controlled trials (RCTs), evaluate the diagnostic and treatment effectiveness of LLMs in the field of ophthalmic diseases, exploring their potential to improve the quality and efficiency of ophthalmic care. 2. Investigating the role of LLMs in medical consultations: Explore the role and effectiveness of LLMs in medical consultations for ophthalmic diseases, including their ability to provide medical advice, explain diagnostic results, and help patients understand treatment plans. 3. Examining the ability of LLMs to adhere to ethical standards: Study how to ensure that LLMs comply with ethical standards and moral principles in ophthalmic medical consultations, safeguarding patient privacy and rights. 4. Providing new technological support for the field of ophthalmology: Through research on the application of LLMs in ophthalmic diseases, offer new technological support and innovations to enhance the quality and efficiency of ophthalmic care. 5. Exploring the differences between LLMs and ophthalmologists: By utilizing multiple large language models, compare the differences between LLMs and ophthalmologists in diagnostic outcomes, case analysis processes, and patient experiences during diagnosis and treatment. 6. Evaluating the effectiveness of LLMs in ophthalmic diseases: Collect patient complaints, fundus images, doctors' diagnoses, and diagnosis times from offline doctor consultations, as well as gather AI-generated medical advice, diagnostic efficiency, and diagnostic accuracy online. Ultimately, conduct comprehensive data analysis to determine the feasibility and effectiveness of LLMs in diagnosing and treating ophthalmic diseases.

Interventions

DIAGNOSTIC_TESTGPT-4o mini;Claude 3 Haiku;Gemini 1.5 Flash;Llama 3.1 7OB;GPT-4o;Claude 3.5 Sonnet;Gemini 1.5 Pro;Llama 3.1 4O5B

Input all the patient's information into the large language model and process it using a pre-defined prompt.

Sponsors

Affiliated Hospital of North Sichuan Medical College
CollaboratorOTHER
North Sichuan Medical College
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* There are patient complaints

Exclusion criteria

* No patient complaints

Design outcomes

Primary

MeasureTime frameDescription
Large Language Model Diagnostics1 weekThe accuracy of the large language model in diagnosing eye diseases

Secondary

MeasureTime frameDescription
Large Language Model Medical Assistance1 weekThe time of diagnosis of eye diseases and other information of the large language model

Other

MeasureTime frameDescription
Large Language Model Medical Explanation1 weekLarge language models diagnose the process of eye disease, attitude to patients, etc

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026