Bronchial Asthma, Cardiomyopathy, Cardiopulmonary Diseases, COPD, Coronary Heart Disease (CHD), Heart Failure, Respiratory Failure, Thoracic Tumors
Conditions
Brief summary
The goal of this clinical trial is to learn if community-based exercise training can benefit patients aged 18 to 85 with diminished cardiovascular and pulmonary function. The main aim of this study is: • Establish a community or home-based fitness training program for patients with cardiopulmonary insufficiency to improve adherence, safety, and efficacy while alleviating the burden on both patients and society. Researchers will compare community-based exercise training to non-exercise training to see if community-based exercise training works to improve cardiovascular and pulmonary function. Participants will: * Engage in community or home exercise training for 40-60 minutes, five times weekly, during a duration of eight weeks. Exercise modalities are primarily determined by the patients' individual preferences and habits, such as brisk walking, running, swimming, cycling, and hiking. * Adjust the exercise intensity according to their cardiopulmonary exercise test and the person's perceived exertion level. * Utilize fitness bracelets or watches to document statistics during workouts and submit them to the experimenter weekly, covering the five days of exercise within that week. * refrain from making any dietary modifications throughout the trial.
Interventions
BEHAVIORALcommunity-based exercise training
The patients will engage in 40-60 minutes of exercise training, either at home or in the community, five times a week, for eight weeks. Brisk walking, jogging, swimming, cycling, and trekking were among the exercise modalities that were chosen mostly based on the patient's individual preferences and habits. To guarantee safe and efficient exercise, exercise intensity was modified based on each person's subjective effort level and the results of their individual cardiorespiratory exercise tests.
Sponsors
Guangdong Provincial People's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
1. Patients aged 18 to 85 with abnormal pulmonary or cardiovascular function. 2. Individuals who have completed a medical screening form to confirm they are free from illnesses and prescription medications that could impair their ability to complete the required testing and fitness training. 3. Participants who did not engage in structured, systematic moderate-to-intense strength or endurance training during the study period (specifically, not within the previous year). 4. At the onset of the trial, participants were physically active but had never participated in formal exercise more than twice a week.
Exclusion criteria
1. Patients with neuromuscular or skeletal disorders, or systemic diseases such as diabetes, cancer, or heart disease. 2. Individuals using medications known to affect health or the interpretation of study results. 3. Participants who have engaged in organized, systematic endurance or strength training of moderate to high intensity within the past year. 4. Patients who decline to participate in the study. 5. Other medical conditions or states that render exercise training inappropriate.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| exercise capacity | at enrollment and week 8 | Peak oxygen uptake (peakVO₂, ml/(kg·min)), measured by cardiopulmonary exercise testing (CPET), refers to the maximum rate of oxygen consumption per unit time during exhaustive incremental exercise. It serves as a key indicator of cardiopulmonary function and aerobic metabolic capacity. |
| life quality | at enrollment and week 8 | The Short Form-36 Health Survey (SF-36) was administered, with scores ranging from 0 to 100 across its eight subscales. Higher scores reflect superior health-related quality of life (HRQoL). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Other exercise capacity outcome | at enrollment and week 8 | Exercise time |
| Leg strength | at enrollment and week 8 | The Nottingham strength test device is used to assess lower limb muscle strength, with a focus on measuring leg extensor power. By calculating the ratio of power output to body weight (power/weight), it indirectly reflects muscle functional status. |
| cardiac function | at enrollment and week 8 | Left ventricular ejection fraction (LVEF, %), measured by Doppler echocardiography, is used to assess left ventricular systolic function, representing the percentage of blood pumped out per heartbeat relative to the left ventricular end-diastolic volume. |
| Blood indices | at enrollment and week 8 | B-type natriuretic peptide (BNP, pg/mL), a key biomarker for heart failure, is used in the diagnosis and therapeutic monitoring of cardiovascular diseases such as heart failure. |
Countries
China
Contacts
Primary ContactBin Zeng
Outcome results
None listed