Angiographic Profiling, Coronary Artery Disease, Non-Diabetic, Premature, Triglycerides Glucose Index
Conditions
Brief summary
This study aims to evaluate the impact of the triglyceride-glucose (TyG) index on the angiographic profiling of non-diabetic patients with premature coronary artery disease (CAD).
Detailed description
Premature coronary artery disease (CAD), defined as CAD occurring before the age of 55 in men and 65 in women, has emerged as a growing health concern worldwide. Insulin resistance and associated metabolic alterations are strongly implicated in premature atherosclerosis. Even in non-diabetic individuals, subclinical insulin resistance promotes endothelial dysfunction, oxidative stress, and low-grade inflammation, leading to early vascular damage. The triglyceride-glucose (TyG) index, calculated using fasting glucose and triglyceride levels, has emerged as a cost-effective surrogate marker for insulin resistance.
Interventions
OTHERCoronary Angiographic Assessment
Coronary angiographic assessment will be performed for all patients.
Sponsors
Sohag University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥18 years old. * Both sexes. * Non-diabetic patients \[no history of diabetes, hemoglobin A1C (HbA1C) \< 6.5%, fasting glucose \< 126 mg/dL\]. * Confirmed diagnosis of coronary artery disease (CAD) by coronary angiography.
Exclusion criteria
* Known diabetes mellitus (type 1 or type 2). * Previous history of coronary revascularization. * Severe hepatic or renal dysfunction \[alanine transaminase (ALT)/aspartate aminotransferase (AST) ≥ 5× upper limit of normal (ULN), estimated glomerular filtration rate (eGFR)\< 30 mL/min/1.73 m²\]. * Malignant disease, autoimmune disease, or systemic inflammatory disorders. * Current use of triglyceride-lowering medications.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of ischemia- driven revascularization | 6 months post-procedure | Incidence of ischemia- driven revascularization will be recorded. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association between triglyceride-glucose index and single-vessel disease | 6 months post-procedure | The association between the triglyceride-glucose (TyG) index and single-vessel disease (SVD) will be recorded. |
| Association between triglyceride-glucose index and two-vessel disease | 6 months post-procedure | The association between the triglyceride-glucose index (TyG) and two-vessel disease (2VD) will be recorded. |
| Association between triglyceride-glucose index and three-vessel disease | 6 months post-procedure | The association between the triglyceride-glucose index (TyG) and three-vessel disease (3VD) will be recorded. |
| Correlation of the triglyceride-glucose index with traditional cardiovascular risk factor | 6 months post-procedure | Correlation of the triglyceride-glucose index with traditional cardiovascular risk factor will be recorded. |
Countries
Egypt
Contacts
Primary ContactRemon S Adly, MD
Outcome results
None listed