Copeptin, Endocan, Preterm Neonates, Respiratory Distress Syndrome, Serum
Conditions
Brief summary
This work aims to investigate and compare the levels of serum endocan and serum copeptin on the first day of life and correlate their levels to the severity of respiratory distress in preterm neonates suffering from respiratory distress syndrome.
Detailed description
Preterm birth continues to be one of the significant challenges in perinatal medicine because of its high incidence of morbidities and mortalities. Its burden on the infant, the family, healthcare systems, and society is enormous. Endocan is implicated in the recruitment of circulating lymphocytes to inflammatory sites and leukocyte adhesion and activation. Endocan also inhibits leukocyte-endothelial cell adhesion and reduces the excessive leukocyte recruitment into the lungs. Copeptin, also known as the arginine vasopressin (AVP) associated glycopeptides. AVP is a vasoactive neurohypophysial hormone. It is one of the primary hormones of the hypothalamic-pituitary-adrenal axis, and its primary function is to regulate water and maintain electrolyte homeostasis. The primary stimulus for AVP release is hyperosmolarity.
Interventions
DIAGNOSTIC_TESTSerum endocan
Serum endocan will be measured by an enzyme-linked immunosorbent assay (ELISA) on the first day of life.
DIAGNOSTIC_TESTSerum copeptin
Serum copeptin will be measured by an enzyme-linked immunosorbent assay (ELISA) on the first day of life.
Sponsors
Tanta University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
28 Weeks to 36 Weeks
Healthy volunteers
No
Inclusion criteria
* Prematurity. * Gestational age between 28 and 36 weeks. * Suffering from respiratory distress syndrome.
Exclusion criteria
* Intrauterine growth restriction (IUGR). * Hypoxic ischemic encephalopathy. * Multiple congenital anomalies. * Chromosomal abnormalities. * Preterm less than 28 weeks. * Neonates with a maternal history of chorioamnionitis (early sepsis). * Infant of diabetic mother. * Prelabor rupture of membranes (PROM)\> 2 hours.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum endocan level for prediction of severity of respiratory distress syndrome | First day of life | Serum endocan level for prediction of severity of respiratory distress syndrome (RDS) will be recorded. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum copeptin level for prediction of severity of respiratory distress syndrome | 5th day of life | Serum copeptin level for the prediction of the severity of respiratory distress syndrome (RDS) will be recorded. |
| Serum endocan level for prediction of mortality | First day of life | Serum endocan level for prediction of mortality will be recorded. |
| Serum copeptin level for prediction of mortality | 5th day of life | Serum copeptin level for prediction of mortality will be recorded. |
Countries
Egypt
Contacts
Primary ContactAsmaa M Elmesiry, MD
Outcome results
None listed