Tooth Extraction Site Healing
Conditions
Brief summary
Sixteen patients with bilateral impacted lower third molars seeking treatment will be recruited from the out-patient clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry at Mansoura University.
Interventions
DEVICEAlb-PRF Autologous Albumin Gel
Socket curettage and bone filing will be done using a bone curette and bone file, respectively. Extraction sockets with albumin gel application. 0.2 ml of autologous albumin gel will be applied to all four edges of the extraction socket
Socket curettage and bone filing will be done using a bone curette and bone file, respectively. Extraction sockets will be left without autologous albumin gel application.
Sponsors
Mansoura University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Healthy patients classified as ASA (American Society of Anesthesiologists) Physical Status Classification Class I. * Patients seeking extraction of both mandibular third molars. * Patients aged 18 - 40 years old by the day of surgery. * Patients willing to participate in the study and commit to regular follow-up appointments.
Exclusion criteria
* Heavy Smokers (more than 25 cigarettes per day). * Patients with Poor oral hygiene. * Patients with history of a chemotherapy or radiotherapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of Facial Swelling (Edema): in Centimeters | first day, third day and seventh day | Measurements will be taken before surgery (baseline). Swelling will be evaluated by comparing the difference between preoperative and postoperative measurements. Swelling will be evaluated in Centimeters using a tape measure. Performed on the patient's operated site using these reference points: * A) Lateral corner of the eye/angle of the mandible * B) Tragus/outer corner of the mouth * C) Tragus/soft tissue pogonion |
| Wound Healing: Disturbed/Not Disturbed | first day, third day and seventh day | The area of operation will be examined for Any manifestations of wound healing disturbance including: * Swelling, redness, hotness, pus discharge, signs and symptoms of infection, Wound dehiscence * Exposure of underlying hard tissue will be carefully noted |
| Postoperative pain severity assessment : using a 10 point Visual Analogue Scale (VAS) | first day, third day and seventh day | Pain will be evaluated using Visual Analogue Scale (VAS). Which is a 10 point scale, in which the minimum end '0" represents no pain, while the maximum end 10" represents the worst pain. |
| Laboratory Assessments of multiple blood/Biochemical markers and their concentrations | first day, third day and seventh day | First 5 cm of blood will be withdrawn under aseptic conditions using sterile venipuncture, then blood will be separated immediately by centrifugation (3000 rpm). To be assessed using enzyme-linked immunosorbent assays (ELISA) kits according to the manufacturer's protocol for their Serum concentrations of: interleukin 6, macrophage inflammatory protein, granulocyte macrophage colony-stimulation factor, and vascular endothelial growth factor |
Countries
Egypt
Outcome results
None listed