Schizophrenia Patients
Conditions
Keywords
Video game, Schizophrenia, Social function, Quality of life
Brief summary
The goal of this clinical trial is to learn if video game-facilitated group activity helps to improve the quality of life and social function in inpatients with chronic schizophrenia. The main questions it aims to answer are: * Does video game-facilitated group activity enhance the quality of life as measured by a standardized scale (WHOQOL) in patients with schizophrenia hospitalized in a psychiatric hospital? * Can video game-facilitated group activity promote social function as measured by a specific scale (PSP) in patients with schizophrenia hospitalized in a psychiatric hospital? Researchers will compare video game-facilitated group activity to regular occupational therapy to see if the intervention is beneficial to patients with chronic schizophrenia. Participants will: * Attend to video game-facilitated group activity or regular occupational therapy three times a week for 12 weeks. * Receive assessments upon and after the 12-week intervention, and another 12 weeks after the intervention ends.
Interventions
BEHAVIORALVideo game-facilitated group activity
The intervention is a 12-week group activity program for each participant in the intervention group, and the program consists of three 50-minute video game facilitated group activity sessions per week. Participants in the intervention group will engage in those group activity session which will be mediated by the game of Super Mario Party on Nintendo Switch.
Sponsors
TsaoTun Psychiatric Center, Department of Health, Taiwan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Individuals aged between \>18 and \<65 years with a principal diagnosis of schizophrenia, as defined by the International Classification of Diseases (ICD-10) codes F20.0-F20.9 which was diagnosed according to DSM-5-TR criteria. * Possessing a valid Catastrophic Illness Certificate for schizophrenia and being continuously hospitalized for more than six months. * Being able to read Chinese and communicate effectively in either Mandarin or Taiwanese. * Being able to comprehend the purpose of the study and to provide written informed consent after the study has been explained by the researchers.
Exclusion criteria
* Individuals exhibiting unstable psychiatric or consciousness conditions, or those unable to comply with video game-based instruction and operation. * Individuals with a history of ocular diseases, severe cardiovascular disorders, epilepsy, or brain injuries; or those who have experienced acute cardiovascular or cerebrovascular events, bone fractures, undergone hip or knee joint replacement, or present with lower limb balance impairments or structural injuries-such as amputations, post-lumbar surgery status, or acute ankle sprains-rendering participation unsuitable within the past six months. * Concurrent participation in other research studies during the study period, where the intervention may potentially influence the primary or secondary outcomes of this study. * Individuals who are legally declared under guardianship.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The changes of quality of life | The outcome will be assessed at baseline, week 12, and week 24. | The changes of quality of life will be assessed by the World Health Organization Quality of Life-BREF (WHOQOL-BREF). |
| The changes of social function. | The outcome will be assessed at baseline, week 12, and week 24 | The changes of social function will be evaluated by the Personal and Social Performance Scale (PSP). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The change of cognitive function. | The outcome will be assessed at baseline and week 12. | The Montreal Cognitive Assessment (MoCA) will be used to evaluate changes in cognitive function. |
| The change of physical fitness | The outcome will be assessed at baseline and week 12. | Physical fitness assessments will be conducted to measure changes in participants' physical fitness levels, including cardiopulmonary endurance, the strength and flexibility of upper and lower limbs, as well as dynamic and static balance. * The cardiopulmonary endurance would be measured by 6-minute walk test and march-in-place test. * The upper limbs strength will be measured by arm curl test and hand grip strength test. * The lower limbs strength will be measured by 30-second chair stand test. * The upper limbs flexibility will be measured by back scratch test. * The lower limbs flexibility will be measured by chair sit-and-reach test. * The dynamic balance test will be measured by chair stand and obstacle walk test. * The static balance test will be measured by one-leg stand test with eyes open. |
| The change of psychiatric symptoms. | The outcome will be assessed at baseline and week 12. | The Brief Psychiatric Rating Scale (BPRS) will be used to assess changes in positive and negative psychiatric symptoms. |
| The changes of cerebral blood flow. | The outcome will be assessed at baseline and week 12. | The changes in cerebral blood be measured by Near-Infrared Spectroscopy (NIRS). |
Other
| Measure | Time frame | Description |
|---|---|---|
| Demographic data | Demographic data will be assessed at baseline. | Demographic data including age, sex, marital status, educational year, body mass index, past medical and allergic history, and other information related with this study will be assessed by research assistants. |
| The change of daily antipsychotic dose equivalences. | This outcome will be assessed at the baseline, Week 12, and Week 24. | The dosage of antipsychotic medications of the participants will be calculated according to their usage of antipsychotic medications that are equivalent to 100 mg/day of chlorpromazine. The daily antipsychotic dose equivalences will be calculated by the average of the daily dose equivalences in the weeks that are scheduled to be assessed. |
Countries
Taiwan
Outcome results
None listed