Inflammatory Biomarkers, Pediatric Anesthesia, Postoperative Nausea and Vomiting (PONV)
Conditions
Keywords
Pediatric anesthesia, Orchiopexy, Postoperative Nausea and Vomiting (PONV), Inflammatory biomarkers
Brief summary
Orchiopexy is a common surgical procedure for the treatment of cryptorchidism in the pediatric population, with a high incidence of postoperative nausea and vomiting (PONV). Recent evidence suggests that systemic inflammation may contribute to PONV pathogenesis, and preoperative inflammatory biomarkers such as NLR, PLR, SII, MLR, and SIRI could serve as predictive indicators. This prospective observational study aims to evaluate the relationship between these biomarkers and PONV incidence in children undergoing orchiopexy.
Interventions
Blood samples will be collected preoperatively to measure inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index, monocyte-to-lymphocyte ratio (MLR), and systemic inflammation response index. These values will be analysed in relation to the incidence of postoperative nausea and vomiting within the first 6 hours after pediatric orchiopexy. No experimental drug or device will be administered as part of the study; all procedures will be conducted within the scope of standard perioperative care.
Sponsors
Diskapi Yildirim Beyazit Education and Research Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Years to 8 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged between 1 and 8 years * Patients with ASA physical status I-II * Patients scheduled for elective orchiopexy * Obtained written informed consent from parents/guardians
Exclusion criteria
* Patients younger than 1 year or older than 8 years * Patients with ASA physical status III or higher * Presence of acute infection signs * History of previous nausea or vomiting
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of Postoperative Nausea and Vomiting (PONV) | Within 6 hours postoperatively | PONV will be assessed using a standardized nausea-vomiting scoring system by an anesthesiologist blinded to biomarker results. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Need for Antiemetic Treatment | Within 6 hours postoperatively | The number of patients who receive at least one dose of rescue antiemetic medication will be recorded within the first 6 hours after surgery. |
Countries
Turkey (Türkiye)
Contacts
Primary ContactElif Şule Özdemir Sezgi
Backup ContactAslı Dönmez
Outcome results
None listed