Ulcerative Colitis
Conditions
Brief summary
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by oxidative stress and recurring inflammation in the colon. The condition can become chronic, spread, and lead to other complications. A key player in the inflammation process is the NLRP3 inflammasome. This inflammasome's expression is heightened and activated by reactive oxygen species (ROS). Its activity is influenced by various factors, including the ubiquitin system, ion channels, and gut microbiota. Rutin, a compound found in many fruits and vegetables, has been shown to have properties that help scavenge free radicals.
Interventions
DRUGRutin 500 MG
Rutin 500 mg capsules twice daily for 30 days
OTHERPlacebo
Placebo Tablets
DIAGNOSTIC_TESTfecal calprotectin
Fecal calprotectin level was measured using an ELISA kit .
Sponsors
Benha University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients presenting with symptoms suggestive of IBD; * Patients with positive microscopic mucosal changes consistent with UC.
Exclusion criteria
* Patients with the presence of recurrent ulceration after surgical treatment, malignancy, or autoimmune disorders.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Success Rate of Treatment Regimens in improving the ulcerative colitis. | 3~4 Months | The proportion of patients who achieved a Simple Clinical Colitis Activity Index (SCCAI) score of 5 or less at the end of the study, which reflects the effectiveness of the treatment. |
Countries
Egypt
Outcome results
None listed