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Predictive Performance of a Generative Model for Corneal Tomography After ICL Implantation

Predictive Performance of a Generative Model for Corneal Tomography After Implantable Collamer Lens Implantation

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07146737
Enrollment
818
Registered
2025-08-28
Start date
2025-07-01
Completion date
2028-12-31
Last updated
2025-08-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

AI (Artificial Intelligence), Deep Learning, ICL, Vault

Keywords

Implantable Collamer Lens (ICL) implantation surgery, Corneal tomography, vault, Artificial Intelligence, Deep Learning

Brief summary

To evaluate the efficacy of a corneal tomography Imaging model in predicting postoperative vault based on preoperative corneal topography in Implantable Collamer Lens (ICL) surgery.

Detailed description

Accurate vault prediction is crucial for Implantable Collamer Lens (ICL) surgery safety and efficacy. Current methods using preoperative biometrics and regression formulas show limited accuracy due to parameter variability and incomplete utilization of corneal topography data. To address this, we developed a deep learning model that predicts postoperative vault while generating anterior chamber morphology images from preoperative data, enabling personalized surgical planning.

Interventions

DIAGNOSTIC_TESTCorneal tomography generation model after ICL surgery

The ICL procedures collected would be assessed by the corneal tomography generation model. The performance of the model would be assessed, including accuracy,AUC, sensitivity and specificity.

Sponsors

Second Affiliated Hospital of Nanchang University
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No

Inclusion criteria

(1) stable myopia (≤0.50D/year change for 2 years), (2) ACD ≥2.80mm, (3) intact corneal endothelium (≥2000 cells/mm²), and (4) no confounding ocular/systemic conditions.

Exclusion criteria

(1) glaucoma-spectrum disorders or retinal vasculopathies, (2) prior corneal/intraocular surgery, (3) compromised corneal endothelium, (4) uncontrolled systemic diseases, and (5) pregnancy/lactation.

Design outcomes

Primary

MeasureTime frameDescription
AUROC of convolutional neural network in predicting vault after ICL surgeryDay 7The area under the receiver operating characteristic of convolutional neural network in predicting vault after ICL surgery

Secondary

MeasureTime frameDescription
Sensitivity and specificity of convolutional neural network in predicting Vault after ICL implantationDay 7Sensitivity and specificity of convolutional neural network in predicting Vault after ICL implantation

Countries

China

Contacts

Primary ContactFu F Gui
564436578@qq.com+8613879101919

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026